Correlates of severity in a clinical staging model of schizophrenia: a cross-sectional study among 158 subjects

BMC Psychiatry

Research

Francois Kazour¹  Fatima Hamieh²  Chadia Haddad³  Souheil Hallit⁴  Sahar Obeid⁵ 

[1] Department of Psychiatry, CHU Angers, Angers, France;Faculty of Sciences, Lebanese University, Fanar, Lebanon;Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon;Institut National de Santé Publique, d’Épidémiologie Clinique et de Toxicologie-Liban (INSPECT-LB), Beirut, Lebanon;School of Health Sciences, Modern University for Business and Science, Beirut, Lebanon;School of Medicine, Lebanese American University, Byblos, Lebanon;School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon;Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon;Applied Science Research Center, Applied Science Private University, Amman, Jordan;Social and Education Sciences Department, School of Arts and Sciences, Lebanese American University, Jbeil, Lebanon;

关键词: Staging;    Schizophrenia;    Psychosis;    Mood;    Antipsychotics;   

DOI  :  10.1186/s12888-023-05144-6

 received in 2023-03-15, accepted in 2023-08-26,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundClinical staging has been widely used to predict and optimize the treatment of medical disorders. Different models have been proposed to map the development, progression, and extension of psychiatric disorders over time, mainly for schizophrenia. The primary objective of this study was to classify patients with psychosis according to the McGorry staging model and compare factors between the different stages.MethodsThis was a cross-sectional study, collecting data from 158 patients hospitalized for schizophrenia/psychosis. The survey included the Mini International Neuropsychiatric Interview (MINI), Positive and Negative Symptom Scale (PANSS), Montgomery-Asberg Depression Rating Scale (MADRS), Yong Mania Rating Scale (YMRS), Clinical Global Impression (CGI) scale, and the McGorry staging model.ResultsPatients have been classified into three clinical stages: relapse of psychotic disorder (43%), multiple relapses (47.5%), and persistent and severe illness (9.5%). A higher mean duration of hospitalization, psychotic symptoms (PANSS total scale and subscales), chlorpromazine equivalent dose, and number of antipsychotic treatments were found among participants in Stage 4 as compared to the other groups. However, a significantly higher mean GAF scale was found among participants in stage 3b as compared to the other groups.ConclusionEach stage in the McGorry staging model of schizophrenia is associated with well-defined clinical presentations, which help decide the appropriate treatment. Using such models in psychiatry can improve the diagnostic process and potential therapeutic interventions for patients suffering from mental disorders.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1