Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years

Arthritis Research & Therapy

Research

Zhaohua Zhu¹  Zhiqiang Wang²  Changhai Ding³  Venkat Parameswaran⁴  Shuang Zheng⁵  Feng Pan⁶  Benny Antony⁶  Leigh Blizzard⁶ 

[1] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China;Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia;Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia;Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia;Department of Endocrinology, Royal Hobart Hospital, 7000, Hobart, TAS, Australia;Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia;

关键词: Vitamin D;    Osteoarthritis;    Knee symptoms;    Depression;    Knee surgery;   

DOI  :  10.1186/s13075-023-03167-8

 received in 2023-05-18, accepted in 2023-09-11,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesThis study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 years in participants with knee osteoarthritis (OA). We also aimed to describe the effect of maintaining sufficient serum vitamin D levels over five years in knee OA.MethodsParticipants (n = 173) from the Hobart centre of the Vitamin D Effects on Osteoarthritis (VIDEO) trial were extensively followed up 3 years after the cessation of 2-year investigational treatment. Participants were classified as maintaining sufficient vitamin D (n = 79) and not maintaining sufficient vitamin D (n = 61) groups.ResultsThere was no significant difference in change in the knee symptoms, depression, and serum levels of IL6 and hs-CRP between both comparisons after 3 years of cessation of the clinical trial. However, among participants who reported no knee surgery (KS), there was a significant improvement in WOMAC function (β: − 83.7, 95% CI: − 167.3, 0) and depression scores (β: − 1.3, 95% CI: − 2.3, − 0.2) in vitamin D group compared to the placebo group. Similarly, those who maintained adequate vitamin D levels over 5 years had significantly less WOMAC knee pain (β: − 33.9, 95% CI: − 65.7, − 2) and physical dysfunction (β: − 105.5, 95% CI: − 198.2, − 12.8) than participants with vitamin D deficiency over 5 years.ConclusionVitamin D supplementation over 2 years or maintaining vitamin D sufficiency for 5 years was not associated with statistically significant differences in change in knee symptom scores over 5 years. However, among participants who did not report KS, 2-year vitamin D supplementation and maintaining sufficient vitamin D was linked to modest improvements in knee symptoms and depression scores in knee OA.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

13690_2023_1170_Article_IEq115.gif

12888_2023_5172_Article_IEq23.gif