Spatiotemporal gait parameter fluctuations in older adults affected by mild cognitive impairment: comparisons among three cognitive dual-task tests

BMC Geriatrics

Research

Chen Liang¹  Tian Yang¹  Xiaojuan Ma¹  Wenzhen Shi¹  Jie Zhang²  Gejuan Zhang²  Jiachen Wang²  Chengxue Du²  Shan Du²  Xiaobo Li²  Huihui Tan²  Yan Mi²  Ye Tian² 

[1] Clinical Medical Research Center, the Affiliated Hospital of Northwest University, Xi’an No.3 Hospital, 710018, Shaanxi, Xi’an, China;Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, the Affiliated Hospital of Northwest University, Xi’an No.3 Hospital, 710018, Shaanxi, Xi’an, China;Department of Neurology, the Affiliated Hospital of Northwest University, Xi’an No.3 Hospital, Shaanxi, 710018, Xi’an, China;Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, the Affiliated Hospital of Northwest University, Xi’an No.3 Hospital, 710018, Shaanxi, Xi’an, China;

关键词: Mild cognitive impairment;    Dual tasks;    Gait analysis;    Spatiotemporal gait parameters;    Aging adults;    Wearable sensors;   

DOI  :  10.1186/s12877-023-04281-7

 received in 2023-01-18, accepted in 2023-09-05,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundsGait disorder is associated with cognitive functional impairment, and this disturbance is more pronouncedly when performing additional cognitive tasks. Our study aimed to characterize gait disorders in mild cognitive impairment (MCI) under three dual tasks and determine the association between gait performance and cognitive function.MethodsA total of 260 participants were enrolled in this cross-sectional study and divided into MCI and cognitively normal control. Spatiotemporal and kinematic gait parameters (31 items) in single task and three dual tasks (serial 100-7, naming animals and words recall) were measured using a wearable sensor. Baseline characteristics of the two groups were balanced using propensity score matching. Important gait features were filtered using random forest method and LASSO regression and further described using logistic analysis.ResultsAfter matching, 106 participants with MCI and 106 normal controls were recruited. Top 5 gait features in random forest and 4 ~ 6 important features in LASSO regression were selected. Robust variables associating with cognitive function were temporal gait parameters. Participants with MCI exhibited decreased swing time and terminal swing, increased mid stance and variability of stride length compared with normal control. Subjects walked slower when performing an extra dual cognitive task. In the three dual tasks, words recall test exhibited more pronounced impact on gait regularity, velocity, and dual task cost than the other two cognitive tests.ConclusionGait assessment under dual task conditions, particularly in words recall test, using portable sensors could be useful as a complementary strategy for early detection of MCI.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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