Prevalence and factors associated with pentavalent vaccination: a cross-sectional study in Southern China

Infectious Diseases of Poverty

Research Article

Yunting Zhang¹  Yujie Cui²  Lichun Fan³  Chuican Huang³  Fan Jiang⁴  Yuanyuan Dong⁵  Guohong Li⁶  Jianing Xu⁶ 

[1] Child Health Advocacy Institute, National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China;Department of Child Health Care, Hainan Women and Children’s Medical Center, Haikou, China;Department of Developmental and Behavioral Pediatrics, National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 227 South Chong Qing Road, 200025, Shanghai, China;Pediatric Translational Medicine Institute, National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China;School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chong Qing Road, 200025, Shanghai, China;Child Health Advocacy Institute, National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chong Qing Road, 200025, Shanghai, China;China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China;

关键词: Early child development;    Pentavalent;    Haemophilus influenzae;    Vaccination coverage;    Influencing factor;    China;   

DOI  :  10.1186/s40249-023-01134-8

 received in 2023-04-30, accepted in 2023-08-31,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundImmunization is one of the most far-reaching and cost-effective strategies for promoting good health and saving lives. A complex immunization schedule, however, may be burdensome to parents and lead to reduced vaccine compliance and completion. Thus, it is critical to develop combination vaccines to reduce the number of injections and simplify the immunization schedule. This study aimed to investigate the current status of the pentavalent diphtheria-tetanus-acellular pertussis inactivated poliomyelitis and Haemophilus influenzae type B conjugate (DTaP-IPV/Hib) vaccination in Southern China as well as explore the factors in the general population associated with uptake and the differences between urban and rural populations.MethodsA cross-sectional study was conducted with recently enrolled kindergarten students in Hainan Province between December 2022 and January 2023. The study employed a stratified multistage cluster random sampling method. Information regarding the demographic characteristics and factors that influence decisions were collected from the caregivers of children via an online questionnaire. Multivariate logistic regression was used to determine the factors associated with the status of DTap-IPV/Hib vaccinations.ResultsOf the 4818 valid responses, 95.3% of children were aged 3–4 years, and 2856 (59.3%) held rural hukou. Coverage rates of the DTaP-IPV/Hib vaccine, from 1 to 4 doses, were 24.4%, 20.7%, 18.5%, and 16.0%, respectively. Caregivers who are concerned about vaccine efficacy [adjusted odds ratio (aOR) = 1.53, 95% confidence interval (CI): 1.30–1.79], the manufacturer (aOR = 2.05, 95% CI: 1.69–2.49), and a simple immunization schedule (aOR = 1.26, 95% CI: 1.04–1.54) are factors associated with a higher likelihood of vaccinating children against DTaP-IPV/Hib. In addition, caregivers in urban areas showed more concern about the vaccine price (P = 0.010) and immunization schedule (P = 0.022) in regard to vaccinating children.ConclusionsThe DTaP-IPV/Hib vaccine coverage rate in Hainan Province remains low. Factors such as lower socioeconomic status, cultural beliefs, concerns about vaccine safety, and cost may hinder caregivers from vaccinating their children. Further measures, such as health education campaigns to raise knowledge and awareness, and encouragement of domestic vaccine innovation, which would reduce out-of-pocket costs, could be implemented to improve the coverage of DTap-IPV/Hib vaccination.Graphical Abstract

【 授权许可】

CC BY   
© National Institute of Parasitic Diseases 2023

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