Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials

Systematic Reviews

Research

Surasak Saokaew¹  Pochamana Phisalprapa²  Sukrit Kanchanasurakit³  Acharaporn Duangjai⁴ 

[1] Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Unit of Excellence On Clinical Outcomes Research and IntegratioN (UNICORN), School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Unit of Excellence On Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Division of Social and Administration Pharmacy, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand;Division of Clinical Pharmacy, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Division of Pharmaceutical Care, Department of Pharmacy, Phrae Hospital, 54000, Phrae, Thailand;Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Unit of Excellence On Clinical Outcomes Research and IntegratioN (UNICORN), School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Unit of Excellence On Herbal Medicine, School of Pharmaceutical Sciences, University of Phayao, 56000, Phayao, Thailand;Unit of Excellence in Research and Product Development of Coffee, Division of Physiology, School of Medical Sciences, University of Phayao, 56000, Phayao, Thailand;

关键词: Green bean coffee;    Chlorogenic acid;    Body weight;    Obesity;    Meta-analysis;   

DOI  :  10.1186/s13643-023-02311-4

 received in 2022-01-23, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSupplemental green bean coffee extract (GBCE) with caffeine has been shown to prevent weight gain. There are different dosages of GBCE that contain chlorogenic acid (CGA), and the data for their effectiveness in preventing weight gain (500 mg/day) is currently out of date. To better understand the effects of GBCE containing CGA on body weight, the present study sets out to perform a systematic review and meta-analysis of these studies.MethodsUsing electronic databases, including Scopus, Embase, PubMed, and Cochrane Library databases, literature was searched up to October 13, 2022. For the meta-analysis examining the impact of GBCE containing CGA (500 mg/day) on body weight with a random-effects model, the randomized controlled trials (RCTs) were considered. We calculated weighted mean differences and 95% confidence intervals (CIs). To gauge study heterogeneity, the Cochran Q statistic and I-squared tests (I2) were employed.ResultsThe meta-analysis includes three RCTs with 103 individuals (case = 51, control = 52). The combined findings of GBCE with CGA at least 500 mg/day result in body weight reduction (WMD: − 1.30 and 95% CI: − 2.07 to − 0.52, p = 0.001) without study heterogeneity (I2 = 0%, p = 0.904) and without publication bias estimated using Egger’s and Begger’s test (p = 0.752 and p = 0.602, respectively).ConclusionsAccording to the meta-analysis, GBCE with CGA 500 mg/day lowers body weight. Nevertheless, despite its limited sample size and short-term study, this study was successful. Long-term research on the effectiveness and safety of GBCE and CGA on body weight require more clinical trials.Systematic review registrationPROSPERO CRD42021254916.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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