Identification of the expression patterns and potential prognostic role of m6A-RNA methylation regulators in Wilms Tumor

BMC Medical Genomics

Research

Mengmeng Chang¹  Changlin Jia¹  Fengyin Sun¹  Xiaoya Liu¹  Wenyue Ma¹  Hongjie Gao² 

[1] Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China;Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China;

关键词: m6A-RNA methylation;    Wilms Tumor;    m6Ascore;    Prognosis;    Tumor immune microenvironment;   

DOI  :  10.1186/s12920-023-01660-2

 received in 2023-02-13, accepted in 2023-09-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo explore the potential role of m6A methylation modification in Wilms Tumor (WT) by m6A-RNA Methylation (m6A) regulators.MethodologyThe association of m6A modification patterns with immune and prognostic characteristics of tumors was systematically evaluated using 19 m6A regulators extracted from Wilms Tumor’s samples in public databases. A comprehensive model of “m6Ascore” was constructed using principal component analysis, and its prognostic value was evaluated.ResultsAlmost all m6A regulators were differentially expressed between WT and normal tissues. Unsupervised clustering identified three distinct m6A clusters that differed in both immune cell infiltration and biological pathways. The m6Ascore was constructed to quantify m6A modifications in individual patients. Our analysis suggests that m6Ascore is an independent prognostic factor for WT and can be used as a novel predictor of WT prognosis.ConclusionsThis study comprehensively explored and systematically characterized m6A modifications in WT. m6A modification patterns play a critical role in the tumor immune microenvironment (TIME) and WT prognosis. m6Ascore provides a more comprehensive understanding of m6A modifications in WT and offers a practical tool for predicting WT prognosis. This study will help clinicians to identify valid indicators of WT to improve the poor prognosis of this disease.Supplementary InformationThe online version contains supplementary material available at https://www.aliyundrive.com/drive/folder/64be739cd6956a741fb24670baeea53422be6024.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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