Clinical characteristics of abruptly increased paediatric patients with Omicron BF.7 or BA.5.2 in Beijing

Virology Journal

Research

Jing Yuan¹  Xiaomei Ma²  Congying Wang²  Yingying Kang²  Rui Sun²  Xiaohui Li²  Lei Yu³  Jian Zhang⁴  Qinglong Gu⁵  Xinning Wang⁶  Daitao Zhang⁷  Bing Lv⁷  Yang Pan⁷  Yu Sun⁸  Linqing Zhao⁸  Runan Zhu⁸  Xiaoyun Li⁸  Yao Yao⁸  Liping Jia⁸ 

[1] Department of Bacteriology, Capital Institute of Pediatrics, 100020, Beijing, China;Department of Cardiology, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Department of Infection Management, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Department of Neurosurgery, Children’s Hospital Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, China;Department of Otorhinolaryngology, Children’s Hospital Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, China;Department of Rheumatology and Immunology, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Control and Prevention, 100013, Beijing, China;Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Disease in Children, Capital Institute of Pediatrics, 100020, Beijing, China;

关键词: Paediatric patients;    Omicron;    Clinical characteristics;    Risk factors;   

DOI  :  10.1186/s12985-023-02177-x

 received in 2023-06-01, accepted in 2023-09-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations of epidemic SARS-CoV-2 strains in paediatric patients.MethodsIn this study, nucleic acid tests (NATs) for SARS-CoV-2 were performed in paediatric outpatients with symptoms of acute respiratory tract infection during 18 Nov–6 Dec, 2022. Half of the outpatients positive for SARS-CoV-2 were randomly selected to screen for other respiratory pathogens, whereas those with low cycle threshold values in SARS-CoV-2 NATs were amplified and sequenced to determine the SARS-CoV-2 variants. Finally, children positive for SARS-CoV-2 with clinical information in detail were enrolled in a follow-up study to identify potential factors significantly associated with long recovery.ResultsAmong 9625 paediatric outpatients tested for nucleic acid of SARS-CoV-2, 733 (7.62%, 733/9625) were identified as SARS-CoV-2 NAT positive, with only three (0.82%, 3/366) co-infected with other pathogens among 366 randomly selected patients, and 71 (62.83%) determined as Omicron subvariant BF.7 and 42 (37.22%) as BA.5.2 among 113 successfully sequenced. Among the 681 patients with complete clinical information, fever was the most common symptom (96.8%). In a follow-up study of 592 patients, 46.96% became asymptomatic on the third day and 65.71% on the fifth day. Only 1.7% of infected children experienced febrile seizures. Combined with abnormal C-reactive protein, a higher percentage of antibiotics administration was observed. More co-living members and longer duration of first symptoms served as independent risk factors for long-term recovery, especially in children vaccinated for SARS-CoV-2.ConclusionsBF.7 and BA.5.2 were the dominate Omicron subvariants and caused milder infections during the SARS-CoV-2 outbreak in Beijing. The number of co-living members and duration of first symptoms were independent risk factors for long-term recovery.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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