期刊论文详细信息
Virology Journal
Clinical characteristics of abruptly increased paediatric patients with Omicron BF.7 or BA.5.2 in Beijing
Research
Jing Yuan1  Xiaomei Ma2  Congying Wang2  Yingying Kang2  Rui Sun2  Xiaohui Li2  Lei Yu3  Jian Zhang4  Qinglong Gu5  Xinning Wang6  Daitao Zhang7  Bing Lv7  Yang Pan7  Yu Sun8  Linqing Zhao8  Runan Zhu8  Xiaoyun Li8  Yao Yao8  Liping Jia8 
[1] Department of Bacteriology, Capital Institute of Pediatrics, 100020, Beijing, China;Department of Cardiology, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Department of Infection Management, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Department of Neurosurgery, Children’s Hospital Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, China;Department of Otorhinolaryngology, Children’s Hospital Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, China;Department of Rheumatology and Immunology, Children’s Hospital Capital Institute of Pediatrics, 100020, Beijing, China;Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Control and Prevention, 100013, Beijing, China;Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Disease in Children, Capital Institute of Pediatrics, 100020, Beijing, China;
关键词: Paediatric patients;    Omicron;    Clinical characteristics;    Risk factors;   
DOI  :  10.1186/s12985-023-02177-x
 received in 2023-06-01, accepted in 2023-09-04,  发布年份 2023
来源: Springer
PDF
【 摘 要 】

BackgroundThe coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations of epidemic SARS-CoV-2 strains in paediatric patients.MethodsIn this study, nucleic acid tests (NATs) for SARS-CoV-2 were performed in paediatric outpatients with symptoms of acute respiratory tract infection during 18 Nov–6 Dec, 2022. Half of the outpatients positive for SARS-CoV-2 were randomly selected to screen for other respiratory pathogens, whereas those with low cycle threshold values in SARS-CoV-2 NATs were amplified and sequenced to determine the SARS-CoV-2 variants. Finally, children positive for SARS-CoV-2 with clinical information in detail were enrolled in a follow-up study to identify potential factors significantly associated with long recovery.ResultsAmong 9625 paediatric outpatients tested for nucleic acid of SARS-CoV-2, 733 (7.62%, 733/9625) were identified as SARS-CoV-2 NAT positive, with only three (0.82%, 3/366) co-infected with other pathogens among 366 randomly selected patients, and 71 (62.83%) determined as Omicron subvariant BF.7 and 42 (37.22%) as BA.5.2 among 113 successfully sequenced. Among the 681 patients with complete clinical information, fever was the most common symptom (96.8%). In a follow-up study of 592 patients, 46.96% became asymptomatic on the third day and 65.71% on the fifth day. Only 1.7% of infected children experienced febrile seizures. Combined with abnormal C-reactive protein, a higher percentage of antibiotics administration was observed. More co-living members and longer duration of first symptoms served as independent risk factors for long-term recovery, especially in children vaccinated for SARS-CoV-2.ConclusionsBF.7 and BA.5.2 were the dominate Omicron subvariants and caused milder infections during the SARS-CoV-2 outbreak in Beijing. The number of co-living members and duration of first symptoms were independent risk factors for long-term recovery.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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