Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

BMC Pediatrics

Research

Catherine S. Birken¹  Cornelia M. Borkhoff²  Teresa To³  Hilary K. Brown⁴  Charles D. G. Keown-Stoneman⁵  Jonathon L. Maguire⁶  Yulika Yoshida-Montezuma⁷  Laura N. Anderson⁸  Russell J. de Souza⁹  David Kirkwood^1,10  Branavan Sivapathasundaram^1,10 

[1] Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada;Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada;Department of Pediatrics, St. Michael’s Hospital, Unity Health Toronto, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada;Women’s College Research Institute, Toronto, ON, Canada;Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;ICES, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;ICES, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;Women’s College Research Institute, Toronto, ON, Canada;Department of Health & Society, University of Toronto Scarborough, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada;Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada;Department of Pediatrics, St. Michael’s Hospital, Unity Health Toronto, Toronto, ON, Canada;Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, L8S 4L8, Hamilton, ON, Canada;Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, L8S 4L8, Hamilton, ON, Canada;Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada;Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street W, L8S 4L8, Hamilton, ON, Canada;Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada;ICES, McMaster University, Hamilton, ON, Canada;

关键词: Late preterm;    Gestational age;    Growth trajectory;    Height;    Weight;    Children;   

DOI  :  10.1186/s12887-023-04257-x

 received in 2023-03-13, accepted in 2023-08-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEvidence suggests that accelerated postnatal growth in children is detrimental for adult cardiovascular health. It is unclear whether children born late preterm (34–36 weeks) compared to full term (≥ 39 weeks), have different growth trajectories. Our objective was to evaluate the association between gestational age groups and growth trajectories of children born between 2006–2014 and followed to 2021 in Ontario, Canada.MethodsWe conducted a retrospective cohort study of children from singleton births in TARGet Kids! primary care network with repeated measures of weight and height/length from birth to 14 years, who were linked to health administrative databases. Piecewise linear mixed models were used to model weight (kg/month) and height (cm/month) trajectories with knots at 3, 12, and 84 months. Analyses were conducted based on chronological age.ResultsThere were 4423 children included with a mean of 11 weight and height measures per child. The mean age at the last visit was 5.9 years (Standard Deviation: 3.1). Generally, the more preterm, the lower the mean value of weight and height until early adolescence. Differences in mean weight and height for very/moderate preterm and late preterm compared to full term were evident until 12 months of age. Weight trajectories were similar between children born late preterm and full term with small differences from 84–168 months (mean difference (MD) -0.04 kg/month, 95% CI -0.06, -0.03). Children born late preterm had faster height gain from 0–3 months (MD 0.70 cm/month, 95% CI 0.42, 0.97) and 3–12 months (MD 0.17 cm/month, 95% CI 0.11, 0.22).ConclusionsCompared to full term, children born late preterm had lower average weight and height from birth to 14 years, had a slightly slower rate of weight gain after 84 months and a faster rate of height gain from 0–12 months. Follow-up is needed to determine if growth differences are associated with long-term disease risk.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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