Functional performance recovery after individualized nutrition therapy combined with a patient-tailored physical rehabilitation program versus standard physiotherapy in patients with long COVID: a pilot study

Pilot and Feasibility Studies

Study Protocol

Joy Demol¹  Elisabeth De Waele¹  Janne Geers¹  Berenice Gabriela Jimenez Garcia²  Lynn Leemans²  Stijn Roggeman³  Ann De Smedt⁴  Marc Schiltz⁴  Koen Putman⁵  David Beckwée⁶ 

[1] Department of Clinical Nutrition and Dietetics, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 101, Laarbeeklaan, 1090, Brussels, Belgium;Department of Clinical Nutrition and Dietetics, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 101, Laarbeeklaan, 1090, Brussels, Belgium;Research Group Rehabilitation Research (RERE), Vrije Universiteit Brussel, 103, Laarbeeklaan, 1090, Brussels, Belgium;Department of Physical Medicine and Rehabilitation, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 101, Laarbeeklaan, 1090, Brussels, Belgium;Department of Physical Medicine and Rehabilitation, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 101, Laarbeeklaan, 1090, Brussels, Belgium;STIMULUS Consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Vrije Universiteit Brussel (VUB), 103, Laarbeeklaan, 1090, Brussels, Belgium;Interuniversity Centre for Health Economics Research (I-CHER), Vrije Universiteit Brussel (VUB), 103, Laarbeeklaan, 1090, Brussels, Belgium;Research Group Rehabilitation Research (RERE), Vrije Universiteit Brussel, 103, Laarbeeklaan, 1090, Brussels, Belgium;

关键词: Long COVID;    Physical exercise;    Nutrition;    Rehabilitation;   

DOI  :  10.1186/s40814-023-01392-1

 received in 2023-01-12, accepted in 2023-09-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLong COVID is suggested to be present in 14 to 43% of COVID 19-survivors. Literature on this new condition states a need for a multidisciplinary approach including physical exercise and nutrition. The aim of the current pilot study is to investigate the feasibility of the proposed protocol to prepare for a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment compared to standard physiotherapy.MethodsThis is a protocol of the UNLOCK (Nutrition and LOComotoric rehabilitation in long COVID) study, a pragmatic, single center, randomized controlled pilot trial with two groups. Patients with persisting symptoms related to a SARS-CoV-2 infection will receive either standard physiotherapy or a personalized multimodal treatment for a period of 12 weeks, consisting of individualized physical exercise program combined with individualized nutritional therapy. They will be followed-up at 6, 12, and 18 weeks after randomization.DiscussionA multidisciplinary approach for dealing with long COVID is needed. Because of the lack of clear data and the fact that this is a very heterogenic group, we aim to prepare and optimize a randomized controlled study that addresses the effectiveness of a personalized multimodal treatment.Trial registrationClinicalTrials.gov Identifier: NCT05254301 (since February 24, 2022).

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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