Autoimmune bullous disorder flares following severe acute respiratory syndrome coronavirus 2 vaccination: a case series

Journal of Medical Case Reports

Case Report

Cody J. Rasner¹  Kimberly Bohjanen²  David R. Pearson²  Brittney Schultz² 

[1] University of Minnesota Medical School, Minneapolis, MN, USA;University of Minnesota Medical School, Minneapolis, MN, USA;Department of Dermatology, University of Minnesota, 516 Delaware St SE, MMC 98, 55455, Minneapolis, MN, USA;

关键词: Bullous pemphigoid;    Pemphigus;    COVID;    SARS-CoV-2;    Vaccination;    Autoimmune;    Case report;   

DOI  :  10.1186/s13256-023-04146-y

 received in 2023-02-14, accepted in 2023-08-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAutoimmune bullous disorders develop due to autoantibodies targeting intercellular adhesion proteins of hemidesmosomes and desmosomes and may be triggered by viral infections and vaccines. Recent reports suggest that the coronavirus disease 2019 vaccination may trigger flares or exacerbations of preexisting autoimmune diseases, including new onset autoimmune bullous disorders. There are less data on whether vaccination against severe acute respiratory syndrome coronavirus 2 may also exacerbate preexisting autoimmune bullous disorders.Case presentationHere we present three cases, two white males (ages 69 years and 88 years) with bullous pemphigoid and one white 50-year-old female with pemphigus foliaceus, wherein all individuals developed minor, tractable flares of their preexisting autoimmune bullous disorders after receiving the coronavirus disease 2019 vaccination, which were readily treatable with topical or low-dose systemic corticosteroids.ConclusionsDermatologists managing patients with autoimmune bullous disorders should be cognizant of the uncommon potential for flares of the disorder following vaccination for severe acute respiratory syndrome coronavirus 2. Flares of bullous pemphigoid and pemphigus foliaceus following vaccination for severe acute respiratory syndrome coronavirus 2 in these cases were mild and tractable.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 5