Rubella virus genotype 2B endemicity and related utility of serum-based molecular characterization in Uganda

BMC Research Notes

Research Note

Prossy Namuwulya¹  Phionah Tushabe¹  Francis Aine¹  James Peter Eliku¹  Molly Birungi¹  Barnabas Bakamutumaho¹  Henry Bukenya¹  Josephine Bwogi¹  Immaculate Ampeire²  Charles R. Byabamazima³  Annet Kisakye⁴ 

[1] EPI-Laboratory, Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda;EPI-Laboratory, Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda;Ministry of Health Uganda, P.O. Box 7272, Kampala, Uganda;EPI-Laboratory, Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda;WHO Inter-Country Support Team Office for Eastern and Southern Africa (IST/ESA), Harare, Zimbabwe;EPI-Laboratory, Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda;World Health Organization, Uganda Country Office, P.O. Box 24578, Kampala, Uganda;

关键词: Rubella;    Congenital Rubella Syndrome;    Genotypes;    Endemic;    Sera;   

DOI  :  10.1186/s13104-023-06499-5

 received in 2022-09-01, accepted in 2023-09-04,  发布年份 2023

来源: Springer

【 摘 要 】

There are 13 globally recognized rubella virus genotypes of which only 2 (1E and 2B) have been detected recently. The largest percentage of all reported rubella virus sequences come from China and Japan with Africa reporting limited data. In a bid to address the lack of rubella genotype data in Uganda and the World Health Organization Africa region, we sought to characterize rubella viruses retrospectively using sera collected from suspected measles patients that turned out rubella IgM positive.Seven sequences belonging to genotype 2B sub-lineage 2B-L2c were obtained. These sequences clustered with other genotype 2B sequences previously reported from Uganda. None of the other genotypes (1E and 1G) reported from Uganda in the earlier years were detected. In addition, none of the sequences were obtained after the introduction of the measles-rubella containing vaccine. The above highlight the need for continuous rubella virological surveillance to confirm interruption of endemic rubella genotype circulation.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 7