Association between gene methylation and experiences of historical trauma in Alaska Native peoples

International Journal for Equity in Health

Research

Alida de Flamingh¹  Mary P. Rogers-LaVanne¹  Ripan S. Malhi²  Alan Boraas³  Alyssa C. Bader⁴  Derek E. Wildman⁵  Monica Uddin⁵  Nathan Moulton⁶  Amelia Wilson⁷  Bernadine Atchison⁸  Sana Saboowala⁹  Rosita Worl^1,10  Chuck Smythe^1,10 

[1] Carl R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA;Carl R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA;Program in Ecology, Evolution and Conservation Biology, University of Illinois at Urbana-Champaign (UIUC), 61801, Urbana, IL, USA;Department of Anthropology, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA;Department of Anthropology, Kenai Peninsula College, 99669, Soldotna, AK, USA;Department of Anthropology, McGill University, H3A 2T7, Montreal, QC, Canada;Sealaska Heritage Institute, 99801, Juneau, AK, USA;Genomics Program, College of Public Health, University of South Florida, 33612, Tampa, FL, USA;Hoonah Indian Association Hoonah, 99829, Hoonah, AK, USA;Huna Heritage Foundation, 99829, Hoonah, AK, USA;Kenaitze Indian Tribe, 99611, Kenai, AK, USA;Program in Ecology, Evolution and Conservation Biology, University of Illinois at Urbana-Champaign (UIUC), 61801, Urbana, IL, USA;Sealaska Heritage Institute, 99801, Juneau, AK, USA;

关键词: Alaska Native peoples;    Community engaged research;    Historical trauma;    Epigenetics;    DNA methylation;   

DOI  :  10.1186/s12939-023-01967-7

 received in 2023-02-01, accepted in 2023-07-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHistorical trauma experienced by Indigenous peoples of North America is correlated with health disparities and is hypothesized to be associated with DNA methylation. Massive group traumas such as genocide, loss of land and foodways, and forced conversion to Western lifeways may be embodied and affect individuals, families, communities, cultures, and health. This study approaches research with Alaska Native people using a community-engaged approach designed to create mutually-beneficial partnerships, including intentional relationship development, capacity building, and sample and data care.MethodsA total of 117 Alaska Native individuals from two regions of Alaska joined the research study. Participants completed surveys on cultural identification, historical trauma (historical loss scale and historical loss associated symptoms scale), and general wellbeing. Participants provided a blood sample which was used to assess DNA methylation with the Illumina Infinium MethylationEPIC array.ResultsWe report an association between historical loss associated symptoms and DNA methylation at five CpG sites, evidencing the embodiment of historical trauma. We further report an association between cultural identification and general wellbeing, complementing evidence from oral narratives and additional studies that multiple aspects of cultural connection may buffer the effects of and/or aid in the healing process from historical trauma.ConclusionA community-engaged approach emphasizes balanced partnerships between communities and researchers. Here, this approach helps better understand embodiment of historical trauma in Alaska Native peoples. This analysis reveals links between the historical trauma response and DNA methylation. Indigenous communities have been stigmatized for public health issues instead caused by systemic inequalities, social disparities, and discrimination, and we argue that the social determinants of health model in Alaska Native peoples must include the vast impact of historical trauma and ongoing colonial violence.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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