Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis

Arthritis Research & Therapy

Research

Xiaoxi Li¹  Yining Wang¹  Youyou Zhang¹  Liru Ge¹  Faming Pan²  Guoqi Cai³  Tania Winzenberg⁴ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, Anhui, China;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, 230032, Hefei, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, Anhui, China;Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia;School of Medicine, University of Tasmania, Hobart, TAS, Australia;Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia;

关键词: Falls;    Fractures;    Hip osteoarthritis;    Knee osteoarthritis;    Recurrent falls;   

DOI  :  10.1186/s13075-023-03179-4

 received in 2023-06-26, accepted in 2023-09-23,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveStudies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA with risk of falls, recurrent falls, and fractures.MethodsWe conducted an electronic search of databases from inception to February 2023. Two authors independently screened studies, extracted data, and assessed the risk of bias using the Newcastle-Ottawa Scale tool in eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models.ResultsOf 17 studies included (n = 862849), 2 had a high risk of bias. Among studies that evaluated falls or fractures as outcomes, 7/8 (87.5%) and 5/11 (45.5%) were self-reported, respectively. Both symptomatic knee and hip OA were associated with increased risk of recurrent falls (knee: OR = 1.55, 95% CI 1.10 to 2.18; hip: OR = 1.50, 95% CI 1.28 to 1.75) but not falls or fractures. Radiographic knee OA increased risk of falls (OR = 1.28, 95% CI 1.03 to 1.59) and did not significantly increase risk of recurrent falls (OR = 1.39, 95% CI 0.97 to 1.97) or fractures (OR = 1.22, 95% CI 0.99 to 1.52). Radiographic hip OA decreased the risk of recurrent falls (OR = 0.70, 95% CI 0.51 to 0.96) but had no statistically significant association with fractures (OR = 1.16, 95% CI 0.79 to 1.71).ConclusionSymptomatic knee and hip OA were both associated with an increased risk of recurrent falls, and radiographic knee OA was associated with an increased risk of falls. No statistically significant associations of radiographic and symptomatic knee or hip OA with fractures were found.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 1