Metabolomics and biomarkers for lupus nephritis – a systematic review

Surgical and Experimental Pathology

Review

Mayara Nanci de Souza¹  Felippe Pereira Barone¹  Giovanna Piacenza Florezi¹  Silvia Vanessa Lourenço¹  Claudia Malheiros Coutinho-Camillo²  Luiz Sergio Azevedo³ 

[1] Department of Stomatology, Faculdade de Odontologia, Universidade de São Paulo, São Paulo, Brasil;International Research Center, A.C.Camargo Cancer Center, São Paulo, Brasil;Kidney Transplantation Unit, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil;

关键词: Lupus nephritis;    Metabolomics;    Chronic kidney disease;    Research;    Review;   

DOI  :  10.1186/s42047-023-00136-y

 received in 2023-03-29, accepted in 2023-07-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe development of personalized medicine using high-throughput methods, such as metabolomics profiling, in discovering and validating biomarkers, may play a key role in the development of new and non-invasive methods for diagnosis and understanding of lupus nephritis (LN).ObjectivesThe aim of this systematic review was to present the current status of metabolomics discovery of biomarkers applied to diagnosing, staging, understanding and treating LN.MethodsThe review was made according to PRISMA guidelines, searching for keywords associated to “Lupus”, “Lupus nephritis”, “Metabolomics” and their variants, with no language restriction, in PUBMED, MEDLINE and EMBASE databases. Full-texts and primary studies in humans including the topics of lupus erythematosus and/or lupus nephritis and used metabolomics in urine and serum as a research method, were included and data analysis was performed individually.ResultsThe search revealed multiple candidates for the diagnosis, staging and prognosis of lupus nephritis, such as citrate, acetate, N-acetyl glycoproteins and various amino acids, as their level in the biofluids of LN patients found in the studies are consistent with the known pathophysiology of LN and inflammatory processes.ConclusionsThe study of metabolomics associated with LN still needs further investigation concerning metabolic pathways and pathogeny. As the community building the databases for the research and annotation of metabolites grow, the use of serum, urine, and saliva in metabolomic profiling, may become a potential non-invasive method in translational medicine studies.

【 授权许可】

CC BY   
© Sociedade Brasileira de Patologia 2023

【 图 表 】

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Fig. 4