Factors affecting the benefit of glasses alone in treating childhood amblyopia: an analysis of PEDIG data

BMC Ophthalmology

Research

María Josefa Luque¹  Rosa T Hernández-Andrés¹  Miguel-Ángel Serrano²  Andrew Scally³  Brendan T Barrett⁴ 

[1] Department of Optics and Optometry and Vision Science, University of Valencia, Doctor Moliner, 50, 46100, Burjassot, Spain;Department of Psychobiology, University of Valencia, Avda. Blasco Ibañez, 13, 46010, Valencia, Spain;School of Clinical Therapies, University College Cork, College Road, T12 K8AF, Cork, Republic of Ireland;School of Optometry & Vision Science, Phoenix South West Building, University of Bradford, BD7 1DP, Bradford, West Yorkshire, UK;

关键词: Amblyopia;    Optical treatment;    Visual acuity;    Stereoacuity;    Interocular difference;   

DOI  :  10.1186/s12886-023-03116-8

 received in 2023-05-02, accepted in 2023-08-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo evaluate factors associated with better outcomes from optical treatment alone in amblyopic children from 3 up to 7 years.MethodsData extracted from two studies with similar protocols, Amblyopic Treatment Studies 5 (n = 152) and 13 (n = 128) from the Pediatric Eye Disease Investigator Group database, were used to determine by regression analysis the factors associated with improvements in visual acuity in the amblyopic eye, inter-ocular visual acuity difference and stereoacuity. Input variables were aetiology of amblyopia (anisometropic, strabismic and combined-mechanism amblyopia), treatment compliance, visual acuity, interocular visual acuity difference, stereoacuity, tropia size at distance and near, age and refractive error at baseline.ResultsDespite the range of clinical factors considered, our models explain only a modest proportion of the variance in optical treatment outcomes. The better predictors of the degree of optical treatment success in amblyopic children are visual acuity of the amblyopic eye, interocular visual acuity difference, stereoacuity, treatment compliance and the amblyopic eye spherical-equivalent refractive error. While the aetiology of the amblyopia does not exert a major influence upon treatment outcome, combined-mechanism amblyopes experience the smallest improvement in visual acuity, tropia and stereoacuity and may need longer optical treatment periods.ConclusionsWhile results identify the factors influencing optical treatment outcome in amblyopic children, clinicians will be unable to predict accurately the benefits of optical treatment in individual patients. Whether this is because relevant clinical or non-clinical factors (e.g. nature and volume of daily activities undertaken) influences the outcomes from optical treatment has not yet been identified and remains to be discovered.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 6

13690_2023_1170_Article_IEq108.gif

12888_2023_5168_Article_IEq4.gif

Fig. 7