Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics

Journal of Hematology & Oncology

Review

Hao-Ran Jin¹  Jin-Lin Yang¹  Jin Wang¹  Bi-Han Xia¹  Ming-Jia Xi¹  Zi-Jing Wang¹  Kai Deng¹ 

[1] Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No.37 Guoxue Road, Wuhou District, 610041, Chengdu, China;Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China;

关键词: Lipid metabolism;    Tumor microenvironment;    Cancer progression;    Immune response;    Targeted therapy;   

DOI  :  10.1186/s13045-023-01498-2

 received in 2023-07-15, accepted in 2023-08-29,  发布年份 2023

来源: Springer

【 摘 要 】

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic reprogramming, which further affects tumor functional phenotypes and immune responses. Given that lipid metabolism plays a critical role in supporting cancer progression and remodeling the tumor microenvironment, targeting the lipid metabolism pathway could provide a novel approach to cancer treatment. This review seeks to: (1) clarify the overall landscape and mechanisms of lipid metabolic reprogramming in cancer, (2) summarize the lipid metabolic landscapes within stromal cells and immune cells in the tumor microenvironment, and clarify their roles in tumor progression, and (3) summarize potential therapeutic targets for lipid metabolism, and highlight the potential for combining such approaches with other anti-tumor therapies to provide new therapeutic opportunities for cancer patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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