Anticandidal effects and chemical compositions of volatile oils extracted from Origanum syriacum, Clinopodium serpyllifolium subsp. fruticosum and Thymbra capitata from Palestine

Chemical and Biological Technologies in Agriculture

Research

Manar Abdalrazeq¹  Mohammad Qadi¹  Abdulraziq Zarour¹  Nawaf Al-Maharik²  Ayat Fuqha³  Nidal Jaradat³  Mohammed Hawash³  Deema Jabareen³  Nayruz Atamni³ 

[1] Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, 7, Nablus, State of Palestine;Department of Chemistry, Faculty of Sciences, An-Najah National University, 7, Nablus, Palestine;Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, 7, Nablus, State of Palestine;

关键词: Origanum syriacum;    Clinopodium serpyllifolium;    Thymbra capitata;    Volatile oils;    Anti-Candida;   

DOI  :  10.1186/s40538-023-00459-8

 received in 2023-02-18, accepted in 2023-08-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOver the past decade, researchers have been exploring the potential therapeutic benefits of volatile oils (VOs) in addressing various disorders, particularly those associated with an increase in fungal infections. This study aimed to analyze the chemical compositions of three different thyme species growing in Palestine using gas chromatography–mass spectroscopy (GC–MS) and explore their antifungal characteristics. The thyme species investigated in this research encompass Origanum syriacum L., Clinopodium serpyllifolium subsp. fruticosum (L.) Bräuchler, and Thymbra capitata (L.) Cav.MethodsThe VOs of the investigated plants were extracted by hydrodistillation technique equipped with Cleavenger apparatus and characterized by utilizing GC–MS equipment. Moreover, the extracted VOs were evaluated for their antifungal activity using the broth microdilution assay against several clinically isolated Candida species and one ATCC strain.ResultsThe GC–MS characterization results of O. syriacum VO revealed the presence of 22 components and the abundant molecules were thymol (37.36%), carvacrol (27.71%), γ-terpinene (17.47%), and p-cymene (7.80%), while 19 compounds were characterized in the C. serpyllifolium VO and the major components were p-cymene (37.58%), carvacrol (22.93%), and γ-terpinene (21.91%). In addition, 23 compounds were identified in T. capitata VO and the main components were carvone (59.45%), pulegone (21.59%), menthone (4.24%), and isomenthone (3.71%). According to the antifungal assay results, VO extracted from O. syriacum has the highest activity among all the screened VOs.ConclusionAll the VOs screened in this study exhibit promising antifungal activities for various potential medical applications. Consequently, we strongly advocate for further biological investigations of these oils in the near future.Graphical Abstract

【 授权许可】

CC BY   
© Springer Nature Switzerland AG 2023

【 图 表 】

Fig. 1