Ocular manifestations following COVID-19 vaccination

Journal of Ophthalmic Inflammation and Infection

Research

Rohit Shetty¹  Sanjay Srinivasan²  Sai Bhakti Mishra²  Padmamalini Mahendradas²  Rohini Sangoram²  Ankush Kawali²  Aditya Patil² 

[1] Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India;Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India;

关键词: COVID-19;    SARS-CoV-2;    Vaccination;    Uveitis;    Scleritis;    Ocular inflammation;    Immunologic;    Coronavirus disease;    Vaccine-associated uveitis;   

DOI  :  10.1186/s12348-023-00358-x

 received in 2022-11-03, accepted in 2023-08-01,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundImmunologic and inflammatory adverse effects following vaccination against COVID-19 are being reported. While some reactions may develop denovo others concern its immunogenic effect in patients with pre-existing inflammatory conditions.MethodsRetrospective consecutive patients diagnosed with ocular inflammatory manifestations within 8 weeks of receiving COVID-19 vaccination who presented to a tertiary eye care centre in South India.ResultsNinety-eight eyes of 67 patients presenting with ocular inflammatory manifestations within 8 weeks following COVID-19 vaccination were studied. The mean age was 43 years (+/- 14.82; range 19–80 years). The most common presentations were anterior uveitis (n = 31, 31.7%), followed by panuveitis (n = 24, 24.5%). The mean time to onset of symptoms was 25 days (+/- 15.48; range 2–55 days) following a dose of vaccine.Among all patients, 39 (58.2%) had a previous history of ocular inflammation. Mean presenting visual acuity was 0.4 (0-4) logMAR units and mean final visual acuity was 0.2 (0-4) logMAR units. The causes for reduced vision included of cystoid macular edema (n=2, 2%), chorioretinal atrophy (n=2.2%), optic atrophy (n=1.1%), retinal vascular occlusion (n=1.1%) and acute retinal necrosis (n=1.1%).ConclusionInfective and immunogenic adverse events should be watched out for after COVID-19 vaccination. It is difficult to establish causality for such manifestations, nevertheless, most of them were mild and had good final visual outcomes.

【 授权许可】

CC BY   
© Springer-Verlag GmbH Germany, part of Springer Nature 2023