Red and golden tomato administration improves fat diet-induced hepatic steatosis in rats by modulating HNF4α, Lepr, and GK expression

Frontiers in Nutrition

Nutrition

Daniela Carlisi¹  Francesca Rappa¹  Giuditta Gambino¹  Giuseppe Giglia²  Giuseppe Ferraro³  Danila Di Majo³  Pierangelo Sardo³  Giulia Lupo⁴  Ayesha Javed⁴  Rosaria Maria Pipitone⁴  Rossella Zito⁴  Gabriele Di Maria⁴  Stefania Grimaudo⁴ 

[1] Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy;Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy;Euro Mediterranean Institute of Science and Technology- I.E.ME.S.T., Palermo, Italy;Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy;Postgraduate School of Nutrition and Food Science, University of Palermo, Palermo, Italy;Department of Health Promotion, Mother and Child Care, Internal Medicine, and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy;

关键词: nonalcoholic fatty liver disease;    golden tomato;    red tomato;    LEPR;    NFH4a;    GK;    lipid homeostasis;    steatosis;   

DOI  :  10.3389/fnut.2023.1221013

 received in 2023-05-11, accepted in 2023-08-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionNonalcoholic fatty liver disease (NAFLD), characterized by lipid accumulation within hepatocytes exceeding 5% of liver weight, is strongly related to metabolic disorders, obesity, and diabetes and represents a health emergency worldwide. There is no standard therapy available for NAFLD. Lifestyle intervention, including phytonutrient intake, is key in preventing NAFLD development and progression.MethodsWe used a rat model of NAFLD to evaluate the effect of dietary supplementation with red tomato (RT) and golden tomato (GT)—a patented mix of fruit with varying degrees of ripeness and particularly rich in naringenin and chlorogenic acid—after steatosis development. We assessed the effects on body weight, metabolic profile, and hepatic steatosis.Results and discussionWe found a correlation between the amelioration of all the parameters and the liver gene expression. Our results showed that, together with the reversion of steatosis, the consumption of RT and GT can cause a significant reduction in triglycerides, low-density lipoprotein-cholesterol, fasting glucose, and homeostasis model assessment index. Meanwhile, we observed an increase in high-density lipoprotein-cholesterol according to the amelioration of the general lipidic profile. Regarding hepatic gene expression, we found the upregulation of Gk and Hnf4α involved in metabolic homeostasis, Lepr involved in adipokine signaling, and Il6 and Tnf involved in inflammatory response. Taken together, our results suggest that dietary intake of red and golden tomatoes, as a nutraceutical approach, has potential in preventing and therapeutics of NAFLD.

【 授权许可】

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Copyright © 2023 Pipitone, Zito, Gambino, Di Maria, Javed, Lupo, Giglia, Sardo, Ferraro, Rappa, Carlisi, Di Majo and Grimaudo.