Ribociclib in newly diagnosed hepatitis B infection: A case report

Frontiers in Oncology

Oncology

Filomena Morisco¹  Valentina Cossiga¹  Gennaro Iengo²  Carmine De Angelis²  Grazia Arpino²  Fabrizio Di Costanzo²  Mario Giuliano²  Simone Carrano²  Amedeo Cefaliello² 

[1] Department of Clinical Medicine and Surgery, Diseases of the Liver and Biliary System Unit, University of Naples “Federico II”, Naples, Italy;Division of Medical Oncology, Department of Clinical Medicine, University of Naples Federico II, Naples, Italy;

关键词: Ribociclib;    hepatitis B;    luminal breast cancer;    CDK4/6 inhibitors;    tenofovir disoproxil fumarate;   

DOI  :  10.3389/fonc.2023.1184952

 received in 2023-03-12, accepted in 2023-05-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Breast cancer is the most frequently diagnosed cancer in women worldwide. Actually CDK4/6 inhibitor Ribociclib is approved for the treatment of metastatic hormone-positive and human epidermal growth factor receptor 2 (HER 2)-negative breast cancer, but comorbidities like infectious or cardiovascular diseases may limit its use.Case reportA 45-year-old woman was diagnosed with metastatic breast cancer in September 2021; also, her hepatitis screening resulted positive for hepatitis B infection. Patient assumed eradicative therapy for hepatitis and bit after started oncological therapy with Ribociclib.OutcomeFrequent check of hepatological function was observed since start of eradicative therapy; liver transaminases and bilirubin kept to not rise despite start of oncological treatment with Ribociclib. Patient’s Performance Status was also not compromised and revaluation at 4, 9 and 13 months showed partial response and then stable disease.Discussionhepatotoxicity of Ribociclib is reported as a possible side effect, and often positivity for hepatitis is cause of exclusion from therapy; in our case, no hepatotoxicity was noted and patient obtained response in terms of control of both infectious and oncological diseases.

【 授权许可】

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Copyright © 2023 Di Costanzo, Carrano, Iengo, Cefaliello, Cossiga, Morisco, Giuliano, De Angelis and Arpino