Intravoxel Incoherent Motion Imaging on Sacroiliitis in Patients With Axial Spondyloarthritis: Correlation With Perfusion Characteristics Based on Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Frontiers in Medicine

Medicine

Qiang Ye¹  Chang Guo¹  Kai Zheng¹  Zhuoyao Xie¹  Zixiao Lu¹  Xin Li¹  Yinghua Zhao² 

[1] Department of Radiology, Academy of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China;null;

关键词: spondyloarthritis;    magnetic resonance imaging;    diffusion-weighted imaging;    intravoxel incoherent motion;    dynamic contrast-enhanced;   

DOI  :  10.3389/fmed.2021.798845

 received in 2021-11-22, accepted in 2021-12-22,  发布年份 2022

来源: Frontiers

【 摘 要 】

BackgroundTo prospectively explore the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) parameters of sacroiliitis in patients with axial spondyloarthritis (axSpA).MethodsPatients with initially diagnosed axSpA prospectively underwent on 3.0 T MRI of sacroiliac joint (SIJ). The IVIM parameters (D, f, D*) were calculated using biexponential analysis. Ktrans, Kep, Ve, and Vp from DCE-MRI were obtained in SIJ. The uni-variable and multi-variable linear regression analyses were used to evaluate the correlation between the parameters from these two imaging methods after controlling confounders, such as bone marrow edema (BME), age, agenda, scopes, and localization of lesions, and course of the disease. Then, their correlations were measured by calculating the Pearson's correlation coefficient (r).ResultsThe study eventually enrolled 234 patients (178 men, 56 women; mean age, 28.51 ± 9.50 years) with axSpA. With controlling confounders, D was independently related to Ktrans (regression coefficient [b] = 27.593, p < 0.001), Kep (b = −6.707, p = 0.021), and Ve (b = 131.074, p = 0.003), whereas f and D* had no independent correlation with the parameters from DCE MRI. The correlations above were exhibited with Pearson's correlation coefficients (r) (r = 0.662, −0.408, and 0.396, respectively, all p < 0.001).ConclusionThere were independent correlations between D derived from IVIM DWI and Ktrans, Kep, and Ve derived from DCE-MRI. The factors which affect their correlations mainly included BME, gender, and scopes of lesions.

【 授权许可】

Unknown   
Copyright © 2022 Guo, Zheng, Ye, Lu, Xie, Li and Zhao.