Incidence and time trends of childhood hematological neoplasms: a 36-year population-based study in the southern European context, 1983–2018

Frontiers in Oncology

Oncology

Cristina Ramírez¹  Patricia Sancho Uriarte²  Marta De-la-Cruz Ortega²  Amaia Aizpurua Atxega²  Maria Araceli Alemán³  Isabel Saez Lloret⁴  Pilar Gutiérrez⁵  Cristina Díaz-del-Campo⁶  María Dolores Chirlaque⁷  María José Sánchez⁸  Marcela Guevara⁹  Ana Isabel Marcos-Navarro^1,10  Marta Rodríguez Camblor^1,11  Jan Trallero^1,12  Arantza Sanvisens^1,12  Rafael Marcos-Gragera^1,13  Josefina Perucha^1,14  Paula Franch^1,15  Noura Jeghalef El Karoni^1,16  Fernando Almela Vich^1,16  Alberto Ameijide^1,17  Jaume Galceran^1,17 

[1] Albacete Cancer Registry, Health and Social Welfare Authority, Albacete, Spain;Basque Country Cancer Registry, Basque Government, Vitoria-Gasteiz, Spain;Canary Islands Cancer Registry, Public Health Directorate, Canary Islands Government, Tenerife, Spain;Cancer Information System of the Valencian Community, Valencian Community Department of Universal Health and Public Health, València, Spain;Castellón Cancer Registry, Directorate General of Public Health and Addictions, Valencian Government, Castellón, Spain;Castilla y León Cancer Registry, Public Health Directorate, Castilla y León Government, Valladolid, Spain;Ciudad Real Cancer Registry, Health and Social Welfare Authority, Ciudad Real, Spain;Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain;Department of Epidemiology, Regional Health Authority, Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca, Murcia University, Murcia, Spain;Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain;Granada Cancer Registry, Andalusian School of Public Health (EASP), Instituto de Investigación Biosanitaria Ibs. GRANADA, University of Granada, Granada, Spain;Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain;Navarra Cancer Registry, Navarra Public Health Institute, Pamplona, Spain;Epidemiology and Public Health Area, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain;Cuenca Cancer Registry, Health and Social Welfare Authority, Cuenca, Spain;Department of Health, Asturias Cancer Registry, Public Health Directorate, Asturias, Spain;Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Catalan Institute of Oncology, Girona Biomedical Research Institute Dr. Josep Trueta (IDIBGI), Girona, Spain;Josep Carreras Leukaemia Research Institute, Badalona, Spain;Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Catalan Institute of Oncology, Girona Biomedical Research Institute Dr. Josep Trueta (IDIBGI), Girona, Spain;Josep Carreras Leukaemia Research Institute, Badalona, Spain;Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain;Nursing, University of Girona, Girona, Spain;La Rioja Cancer Registry, Epidemiology and Health Prevention Service, Logroño, Spain;Mallorca Cancer Registry, Public Health and Participation Department, Palma de Mallorca, Spain;Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain;Registry of Childhood and Adolescent Tumors of the Valencian Community, Valencian Community Department of Universal Health and Public Health, València, Spain;Cancer Information System of the Valencian Community, Valencian Community Department of Universal Health and Public Health, València, Spain;Tarragona Cancer Registry, Cancer Epidemiology and Prevention Service, Sant Joan de Reus University Hospital, Tarragona, Spain;Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, Spain;

关键词: incidence;    childhood;    hematological neoplasms;    incidence trends;    leukemia-lymphoma;    population-based registries;   

DOI  :  10.3389/fonc.2023.1197850

 received in 2023-03-31, accepted in 2023-07-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundHematological neoplasms (HNs) are the first and most common childhood cancers globally. Currently, there is a lack of updated population-based data on the incidence of these cancers in the Spanish pediatric population. This study aimed to describe the incidence and incidence trends of HNs in children (0–14 years) in Spain using data from the Spanish Network of Cancer Registries and to compare the results with other southern European countries.MethodsData were extracted from 15 Spanish population-based cancer registries between 1983 and 2018. Cases were coded according to the International Classification of Diseases for Oncology, third edition, first revision, and grouped according to the International Classification of Childhood Cancer, third edition. Crude rates (CRs), age-specific rates, and age-standardized incidence rates using the 2013 European population (ASRE) were calculated and expressed as cases per 1,000,000 child-years. Incidence trends and annual percentage changes (APCs) were estimated.ResultsA total of 4,747 HNs were recorded (59.5% boys). Age distribution [n (%)] was as follows: <1 year, 266 (5.6%); 1–4 years, 1,726 (36.4%); 5–9 years, 1,442 (30.4%); and 10–14 years, 1,313 (27.6%). Leukemias were the most common group, with a CR and an ASRE of 44.0 (95%CI: 42.5; 45.5) and 44.1 (95%CI: 42.6; 45.7), respectively. The CR and ASRE of lymphomas were 20.1 (95%CI: 19.1; 21.1) and 20.0 (95%CI: 19.0; 21.1), respectively. The comparable incidence rates between our results and those of other southern European countries were similar for lymphomas, while some differences were observed for leukemias. From 1988 to 2016, the trend in leukemia incidence was stable for both sexes, with an APC of 0.0 (95%CI: −0.5; 0.7), whereas a constant overall increase was observed for lymphoma in both sexes, with an APC of 1.0 (95%CI: 0.4; 1.6).ConclusionLeukemias are the most common HNs in children, and their incidence has remained stable since 1988, whereas the incidence of lymphomas has increased every year. Lymphoma incidence is like that of other southern European countries, while leukemia incidence is similar only to that of southwestern European countries. Collaborative cancer registry projects allow for assessing epidemiological indicators for cancers such as HNs, which helps health authorities and clinicians provide more knowledge about these malignancies.

【 授权许可】

Unknown   
Copyright © 2023 Trallero, Sanvisens, Almela Vich, Jeghalef El Karoni, Saez Lloret, Díaz-del-Campo, Marcos-Navarro, Aizpurua Atxega, Sancho Uriarte, De-la-Cruz Ortega, Sánchez, Perucha, Franch, Chirlaque, Guevara, Ameijide, Galceran, Ramírez, Camblor, Alemán, Gutiérrez, Marcos-Gragera and REDECAN