Cutaneous malignancies in patients with Parkinson’s disease at a dermato-oncological university centre in Hungary

Frontiers in Oncology

Oncology

Béla Tóth¹  Enikő Kuroli¹  József Szakonyi¹  Sarolta Kárpáti¹  Veronika Tóth¹  Kende Kálmán Lőrincz¹  Péter Holló¹  Daniella Kuzmanovszki¹  Beáta Somlai¹  Stefani Christina Diakoumakou² 

[1] Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary;General Hospital Sismanoglio-Amalia Fleming, Athens, Greece;

关键词: Parkinson’s disease;    risk;    skin malignancy;    melanoma;    nonmelanoma skin cancer;   

DOI  :  10.3389/fonc.2023.1142170

 received in 2023-01-11, accepted in 2023-05-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe possible correlation between melanoma and Parkinson’s disease (PD) has been intensively studied. In this work, we aimed to assess the coincidence of skin malignancies and PD at a dermato-oncological university centre in Central-Eastern Europe, Hungary.MethodsFrom 2004 to 2017, a retrospective analysis of the centre’s database was performed based on International Statistical Classification of Diseases-10 codes.ResultsOut of the patients who visited the clinic during the study period, 20,658 were treated for malignant skin tumours. Over the 14 years, 205 dermatological patients had PD simultaneously, 111 (54%) of whom had at least one type of skin malignancy: melanoma (n=22), basal cell carcinoma (BCC) (n=82), or squamous cell carcinoma (SCC) (n=36) (in some patients, multiple skin tumours were identified). Compared to the age- and sex-matched control group, patients with PD had a significantly lower risk for basal cell carcinoma (OR, 0.65; 95% CI, 0.47–0.89, p=0.0076) and for all skin tumours (OR, 0.74; 95% CI, 0.56–0.98, p=0.0392) but not for melanoma.ConclusionsWe found a decreased risk of all skin tumours and basal cell carcinoma and an unchanged risk of melanoma among patients with PD. However, it should be kept in mind that some large-scale meta-analyses suggest a higher incidence of melanoma after a diagnosis of PD, indicating the importance of skin examination in this vulnerable population.

【 授权许可】

Unknown   
Copyright © 2023 Tóth, Diakoumakou, Kuroli, Tóth, Kuzmanovszki, Szakonyi, Lőrincz, Somlai, Kárpáti and Holló