An exploratory study of unexplained concentration of 18F-PSMA-1007 in the bladder for prostate cancer PET/CT imaging

Frontiers in Medicine

Medicine

Yingchun Li¹  Yi Zhao²  Meng Zhao²  Zhuzhong Cheng²  Shiwei Qing²  Jun Dang²  Xiaofei Tan²  Xiao Jiang²  Hao Lu²  Shirong Chen²  Yutang Yao²  Ying Kou²  Zhenyan Ye² 

[1] Department of Nuclear Medicine and Radiotherapy, Air Force Hospital of Western Theater Command, Chengdu, China;Department of Nuclear Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China;

关键词: prostate cancer;    F-PSMA-1007;    PET;    bladder uptake;    positron emission tomography;   

DOI  :  10.3389/fmed.2023.1238333

 received in 2023-06-11, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

18F-PSMA-1007 PET/CT imaging is increasingly used for the diagnosis, staging, and efficacy assessment of patients with prostate cancer. Compared with other PSMA tracers, 18F-PSMA-1007 is mainly cleared by the liver and bile and has lower urinary clearance, thus allowing a better assessment of the lesions around the bladder. However, there were some patients who showed an obvious concentration of the 18F-PSMA-1007 in the bladder, which may affect the observation of peripheral lesions, but the mechanism of this change is unknown. The aim of this study was to explore the cause of bladder 18F-PSMA-1007 concentration by assessing the clinical and imaging characteristics of 18F-PSMA-1007 PET/CT scans. A total of 284 patients were included in this retrospective study, and their clinical characteristics such as age, height, weight, Gleason score, metastases, different treatment methods, the level of liver and kidney function, PSA level, and imaging characteristics such as 18F-PSMA-1007 injected activity, the interval between injection to scan, physiological distribution (parotid gland, kidney, liver, spleen, intestine, obturator internus), pathological distribution (prostate lesions, metastases) were collected, and were compared after subgrouping using bladder urine SUVmax. This study showed that the distribution of bladder 18F-PSMA-1007 was not correlated with the above clinical and imaging characteristics, so further studies are needed to find the explanations, and thus to improve the disease assessment of this type of prostate cancer patients.

【 授权许可】

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Copyright © 2023 Dang, Yao, Li, Tan, Ye, Zhao, Qing, Kou, Jiang, Lu, Chen, Zhao and Cheng.