Case report: Atypical Parkinsonism following SARS-CoV-2 infection

Frontiers in Neurology

Neurology

Adriano Chiò¹  Tiziana De Santis²  Elena Perdixi²  Paola Polverino²  Alberto Albanese³ 

[1] ALS Centre “Rita Levi Montalcini,” Department of Neuroscience, University of Turin, Turin, Italy;Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, Turin, Italy;Department of Neurology, IRCCS Humanitas Research Hospital, Milan, Italy;Department of Neurology, IRCCS Humanitas Research Hospital, Milan, Italy;Department of Neuroscience, Catholic University, Rome, Italy;

关键词: COVID-19;    multiple system atrophy;    Parkinsonism;    SARS-CoV-2;    diagnosis;   

DOI  :  10.3389/fneur.2023.1208213

 received in 2023-04-18, accepted in 2023-07-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

A wide range of neurological manifestations have been reported during the COVID-19 pandemic, including a variety of Parkinsonian cases. The association of numerous viruses with the development of persistent or transient Parkinsonism has been well-documented. We observed a patient who developed a levodopa non-responsive Parkinsonian syndrome with dysautonomia during a prolonged stay at home for COVID-19. Although the temporal proximity of the emerging Parkinsonian features with a COVID-19 diagnosis suggested a causal relationship, we considered the possibility of a coincidental occurrence of multiple system atrophy. We discuss the patient's clinical features in relation to the established clinical diagnostic criteria and review differential diagnoses as well as the role of SARS-CoV-2 infection.

【 授权许可】

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Copyright © 2023 Polverino, De Santis, Perdixi, Chiò and Albanese.