Function of reactive oxygen species in myeloid-derived suppressor cells

Frontiers in Immunology

Immunology

Kai Yin¹  Jiaojiao Huang²  Yue Zhao²  Kexin Zhao²  Shengjun Wang³ 

[1] Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China;Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China;Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China;Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China;

关键词: MDSCs;    ROS;    immunotherapy;    tumor;    tumor micro environment (TME);   

DOI  :  10.3389/fimmu.2023.1226443

 received in 2023-05-21, accepted in 2023-07-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population and serve as a vital contributor to the tumor microenvironment. Reactive oxygen species (ROS) are byproducts of aerobic respiration and are involved in regulating normal biological activities and disease progression. MDSCs can produce ROS to fulfill their immunosuppressive activity and eliminate excessive ROS to survive comfily through the redox system. This review focuses on how MDSCs survive and function in high levels of ROS and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Zhao, Zhao, Yin and Wang