Frontiers in Immunology | |
Intraperitoneal metastasis of ovarian cancer: new insights on resident macrophages in the peritoneal cavity | |
Immunology | |
Nan Zhang1  Taito Miyamoto1  Brennah Murphy1  | |
[1] Immunology, Metastasis & Microenvironment Program, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States; | |
关键词: ovarian cancer; intraperitoneal metastasis; resident macrophages; peritoneal cavity; peritoneal fluid; peritoneum; omentum; | |
DOI : 10.3389/fimmu.2023.1104694 | |
received in 2022-11-21, accepted in 2023-04-13, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Ovarian cancer metastasis occurs primarily in the peritoneal cavity. Orchestration of cancer cells with various cell types, particularly macrophages, in the peritoneal cavity creates a metastasis-favorable environment. In the past decade, macrophage heterogeneities in different organs as well as their diverse roles in tumor settings have been an emerging field. This review highlights the unique microenvironment of the peritoneal cavity, consisting of the peritoneal fluid, peritoneum, and omentum, as well as their own resident macrophage populations. Contributions of resident macrophages in ovarian cancer metastasis are summarized; potential therapeutic strategies by targeting such cells are discussed. A better understanding of the immunological microenvironment in the peritoneal cavity will provide a stepping-stone to new strategies for developing macrophage-based therapies and is a key step toward the unattainable eradication of intraperitoneal metastasis of ovarian cancer.
【 授权许可】
Unknown
Copyright © 2023 Miyamoto, Murphy and Zhang
【 预 览 】
Files | Size | Format | View |
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RO202310109708947ZK.pdf | 2595KB | download |