Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study

Frontiers in Oncology

Oncology

Kun Liu¹  Zhao Wei²  Wenqi Hui³  Yuegui Tan³  Yuzhen Qin⁴ 

[1] Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University, Xi’an, Shaanxi, China;Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi’an, Shaanxi, China;Department of Pharmacy, Xi’an Fifth Hospital, Xian, Shaanxi, China;Xi’an Jiaotong-liverpool University, XJTLU Wisdom Lake Academy of Pharmacy, Xian, Shaanxi, China;

关键词: gastric cancer;    Mendelian randomization;    smoking;    alcohol consumption;    tea intake;    coffee intake;   

DOI  :  10.3389/fonc.2023.1224753

 received in 2023-06-25, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundEpidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them.MethodsTwo-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR.Raps), MR using a Robust Adjusted Profile Score (MR-PRESSO), Radial regression of MR, and Causal Analysis Using Summary Effect Estimates (CAUSE). A sensitivity analysis was conducted to assess the robustness of the results.ResultsIn an East Asian population, we found that increased tea intake reduced the risk of GC [odds ratio (OR)= 0.90, 95% confidence interval (CI)= 0.82-0.99, P = 0.037] while there was a positive association between smoking and GC (OR = 1.58, 95% CI = 1.04-2.39, P = 0.032). No causal relationship between alcohol and coffee intake and GC. Sensitivity analyses demonstrated the robustness of these causal associations.ConclusionsOur study suggests that tea intake may reduce the risk of GC, for which smoking is a potential risk factor. Nevertheless, a larger and more diverse sample size is needed for further validation.

【 授权许可】

Unknown   
Copyright © 2023 Tan, Wei, Liu, Qin and Hui