Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis

Frontiers in Immunology

Immunology

Sarah Straub¹  Natalia G. Sampaio¹ 

[1] Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia;Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash University, Clayton, VIC, Australia;

关键词: RNA;    interferon;    MDA5;    RIG-I;    PKR;    OAS (2′5′-oligoadenylate synthetase);    ZBP1;    LGP2;   

DOI  :  10.3389/fimmu.2023.1092790

 received in 2022-11-08, accepted in 2023-05-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Early detection of infection is a central and critical component of our innate immune system. Mammalian cells have developed specialized receptors that detect RNA with unusual structures or of foreign origin – a hallmark of many virus infections. Activation of these receptors induces inflammatory responses and an antiviral state. However, it is increasingly appreciated that these RNA sensors can also be activated in the absence of infection, and that this ‘self-activation’ can be pathogenic and promote disease. Here, we review recent discoveries in sterile activation of the cytosolic innate immune receptors that bind RNA. We focus on new aspects of endogenous ligand recognition uncovered in these studies, and their roles in disease pathogenesis.

【 授权许可】

Unknown   
Copyright © 2023 Straub and Sampaio