“InMotion”—Mixed physical exercise program with creative movement as an intervention for adults with schizophrenia: study protocol for a randomized controlled trial

Frontiers in Human Neuroscience

Neuroscience

Mussie Msghina¹  Mats Eriksson²  Majja Lund²  Hanna Poikonen³  Margareta Möller⁴  Anna Duberg⁴  Martin Eriksson-Crommert⁵ 

[1] Department of Psychiatry, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden;Faculty of Medicine and Health, School of Health Sciences, Örebro University, Örebro, Sweden;Professorship for Learning Sciences and Higher Education, Department of Humanities, Social and Political Sciences, Swiss Federal Institute of Technology Zurich (ETH Zürich), Zürich, Switzerland;University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Faculty of Medicine and Health, School of Health Sciences, Örebro University, Örebro, Sweden;University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden;

关键词: schizophrenia;    physical activity;    brain imaging;    Motion Capture;    physical therapy;    rehabilitation medicine;    dance;   

DOI  :  10.3389/fnhum.2023.1192729

 received in 2023-03-23, accepted in 2023-06-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundSchizophrenia is among the world’s top 10 causes of long-term disability with symptoms that lead to major problems in social and occupational functioning, and in self-care. Therefore, it is important to investigate the efficacy of complementary treatment options for conventionally used antipsychotic medication, such as physical training, and psychosocial interventions.ObjectiveTo combine aerobic and strength training with cognitive, emotional and social stimulation in one intervention for people with schizophrenia and test the feasibility and effects of this intervention.MethodsThe study is a mixed-method randomized controlled trial to evaluate the effects of a 12-week intervention for adults with schizophrenia. The treatment group (30 participants) will receive the intervention in addition to standard care and the control group (30 participants) only standard care. The intervention consists of 24 biweekly sessions with a duration of 60 min. The pre-test (weeks from 4 to 2 prior to the intervention) and post-test (week 12) include clinical measure (PANSS), quality of life, social performance, movement quantity, brain function and eye tracking measures. In addition, a treatment subgroup of 12–15 participants and their family member or other next of kin will complete a qualitative interview as a part of their post-test. Two follow-up tests, including clinical, quality of life, brain function and eye tracking will be made at 6 and 12 months from the completion of the intervention to both study groups. The primary outcome is change in negative symptoms. Secondary outcome measures include general and positive symptoms, quality of life, social performance, movement quantity, brain function and eye tracking. Explorative outcome includes patient and family member or other next of kin interview.ResultsPilot data was collected by June 2023 and the main data collection will begin in September 2023. The final follow-up is anticipated to be completed by 2026.ConclusionThe InMotion study will provide new knowledge on the feasibility, efficacy, and experiences of a novel intervention for adults with schizophrenia. The hypothesis is that regular participation in the intervention will reduce clinical symptoms, normalize physiological measures such as brain activation, and contribute to new active habits for the participants.Trial registrationClinicalTrials.gov, identifier NCT05673941.

【 授权许可】

Unknown   
Copyright © 2023 Poikonen, Duberg, Eriksson, Eriksson-Crommert, Lund, Möller and Msghina.