High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities

Frontiers in Medicine

Medicine

DeLisa Fairweather¹  Archana Kotha¹  Angita Jain¹  Ashley A. Darakjian¹  Katelyn A. Bruno²  Bala Munipalli³  Pedro A. Malavet³  Dacre R. T. Knight³  Fernando A. Rivera³  Jessica M. Gehin³  Todd D. Rozen⁴  Barbara K. Bruce⁵  David O. Hodge⁶  Zhongwei Peng⁶ 

[1] Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States;Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States;Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States;Department of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States;Department of Neurology, Mayo Clinic, Jacksonville, FL, United States;Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States;Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States;

关键词: fibromyalgia;    hypermobile Ehlers-Danlos syndrome (hEDS);    hypermobility spectrum disorders;    chronic disease;    pain;    abuse;    allergy;    women’s health;   

DOI  :  10.3389/fmed.2023.1096180

 received in 2022-11-15, accepted in 2023-04-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundJoint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS/HSD and/or fibromyalgia.MethodsWe retrospectively examined self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS/HSD, fibromyalgia, or both vs. controls with an emphasis on joint issues.ResultsFrom 733 patients seen at the EDS Clinic, 56.5% (n = 414) were diagnosed with hEDS/HSD and fibromyalgia (Fibro), 23.8% (n = 167) hEDS/HSD, 13.3% (n = 98) fibromyalgia, or 7.4% (n = 54) none of these diagnoses. More patients were diagnosed with HSD (76.6%) than hEDS (23.4%). Patients were primarily White (95%) and female (90%) with a median age in their 30s (controls 36.7 [18.0, 70.0], fibromyalgia 39.7 [18.0, 75.0], hEDS/HSD 35.0 [18.0, 71.0], hEDS/HSD&Fibro 31.0 [18.0, 63.0]). There was high overlap in all 40 symptoms/comorbidities that we examined in patients diagnosed with fibromyalgia only or hEDS/HSD&Fibro, regardless of whether they had hEDS or HSD. Patients that only had hEDS/HSD without fibromyalgia had far fewer symptoms/comorbidities than patients with hEDS/HSD&Fibro. The top self-reported issues in patients that only had fibromyalgia were joint pain, hand pain when writing or typing, brain fog, joint pain keeping from daily activities, allergy/atopy and headache. Five issues that significantly and uniquely characterized patients diagnosed with hEDS/HSD&Fibro were subluxations (dislocations in hEDS patients), joint issues like sprains, the need to stop sports due to injuries, poor wound healing, and migraine.ConclusionThe majority of patients seen at the EDS Clinic had a diagnosis of hEDS/HSD plus fibromyalgia that was associated with more severe disease. Our findings indicate that fibromyalgia should be routinely assessed in patients with hEDS/HSD and vis-a-versa to improve patient care.

【 授权许可】

Unknown   
Copyright © 2023 Fairweather, Bruno, Darakjian, Bruce, Gehin, Kotha, Jain, Peng, Hodge, Rozen, Munipalli, Rivera, Malavet and Knight.