Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana

Frontiers in Immunology

Immunology

Karim Aoun¹  Aida Bouratbine¹  Sylviane Pied²  Ghislaine Prévot²  Pierre André Cazenave²  Magalie Demar³  Romain Blaizot³  Nasreddine Saidi⁴ 

[1] Laboratoire de Recherche, LR 16-IPT-06, Parasitoses Médicales, Biotechnologies et Biomolécules, Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, Tunisia;Service de Parasitologie-Mycologie, Institut Pasteur de Tunis, Tunis, Tunisia;Univ. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, France;Univ. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, France;Centre National de Référence des Leishmanioses, Laboratoire Associé, Hôpital Andrée Rosemon, Cayenne, French Guiana, France;Service de Dermatologie, Hôpital de Cayenne, Cayenne, French Guiana, France;Univ. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, France;Laboratoire de Recherche, LR 16-IPT-06, Parasitoses Médicales, Biotechnologies et Biomolécules, Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, Tunisia;

关键词: L. major;    L. infantum;    L. tropica;    L. guyanensis;    L. braziliensis;    cutaneous leishmaniasis (CL);    clinical manifestation;    local immune response;   

DOI  :  10.3389/fimmu.2023.1134020

 received in 2022-12-29, accepted in 2023-03-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parameters, the evolution of lesions is determined by a complex interaction between parasite factors and the early immune responses triggered, including innate and adaptive mechanisms. Moreover, lesion resolution requires parasite control as well as modulation of the pathologic local inflammation responses and the initiation of wound healing responses. Here, we have summarized recent advances in understanding the in situ immune response to cutaneous leishmaniasis: i) in North Africa caused by Leishmania (L.) major, L. tropica, and L. infantum, which caused in most cases localized autoresolutives forms, and ii) in French Guiana resulting from L. guyanensis and L. braziliensis, two of the most prevalent strains that may induce potentially mucosal forms of the disease. This review will allow a better understanding of local immune parameters, including cellular and cytokines release in the lesion, that controls infection and/or protect against the pathogenesis in new world compared to old world CL.

【 授权许可】

Unknown   
Copyright © 2023 Saidi, Blaizot, Prévot, Aoun, Demar, Cazenave, Bouratbine and Pied