Lipid-based nanoparticles via nose-to-brain delivery: a mini review

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Tan Jing¹  Yang Xinchen¹  Guan Jiaoqiong² 

[1] Department of Neurology, West China Hospital, Sichuan University, Chengdu, China;Department of Neurology, West China Hospital, Sichuan University, Chengdu, China;Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China;

关键词: nanoparticles;    nose-to-brain;    blood-brain barrier;    drug delevery;    central nervous system;   

DOI  :  10.3389/fcell.2023.1214450

 received in 2023-04-29, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Central nervous system disorders significantly affect the lives and health of millions of people worldwide. Despite many therapeutic drugs are available that could potentially target central nervous system disorders, their clinical utility is severely constrained by their inability to cross the blood-brain barrier (BBB). Fortunately, nanotechnology has been advanced to offers a solution to allow drugs reaching the targeted brain regions safely, efficiently, and precisely through nasal drug delivery system (NDDS), bypassing the BBB completely. This strategy can promote the drug accumulated in the targeted brain region, improve drug bioavailability, and minimal side effects and mucociliary clearance effectively. In this review, we elaborate recent advances in the use of lipid-based nanoparticles, involving liposomes, nanoemulsions, nanostructured lipid carriers, and solid lipid nanoparticles. Besides, we particularly introduced the nasal cavity physiological structure, and further summarized the nose-to-brain drug delivery pathways, including olfactory, trigeminal, and blood circulation pathway. Moreover, the mechanism and route of NDDS by various types of nanoparticles are also highlighted.

【 授权许可】

Unknown   
Copyright © 2023 Xinchen, Jing and Jiaoqiong.