Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer

Frontiers in Immunology

Immunology

Julia Erber¹  Dietmar Herndler-Brandstetter¹ 

[1] Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

关键词: noncoding RNA;    tumor-infiltrating T cell;    regulatory T cell;    gamma delta T cell;    exhaustion;    dysfunction;    tumor immune evasion;    adoptive cell therapy;   

DOI  :  10.3389/fimmu.2023.1181499

 received in 2023-03-07, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Long noncoding RNAs (lncRNAs) increase in genomes of complex organisms and represent the largest group of RNA genes transcribed in mammalian cells. Previously considered only transcriptional noise, lncRNAs comprise a heterogeneous class of transcripts that are emerging as critical regulators of T cell-mediated immunity. Here we summarize the lncRNA expression landscape of different T cell subsets and highlight recent advances in the role of lncRNAs in regulating T cell differentiation, function and exhaustion during homeostasis and cancer. We discuss the different molecular mechanisms of lncRNAs and highlight lncRNAs that can serve as novel targets to modulate T cell function or to improve the response to cancer immunotherapies by modulating the immunosuppressive tumor microenvironment.

【 授权许可】

Unknown   
Copyright © 2023 Erber and Herndler-Brandstetter