Frontiers in Immunology | |
Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer | |
Immunology | |
Julia Erber1  Dietmar Herndler-Brandstetter1  | |
[1] Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; | |
关键词: noncoding RNA; tumor-infiltrating T cell; regulatory T cell; gamma delta T cell; exhaustion; dysfunction; tumor immune evasion; adoptive cell therapy; | |
DOI : 10.3389/fimmu.2023.1181499 | |
received in 2023-03-07, accepted in 2023-05-02, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Long noncoding RNAs (lncRNAs) increase in genomes of complex organisms and represent the largest group of RNA genes transcribed in mammalian cells. Previously considered only transcriptional noise, lncRNAs comprise a heterogeneous class of transcripts that are emerging as critical regulators of T cell-mediated immunity. Here we summarize the lncRNA expression landscape of different T cell subsets and highlight recent advances in the role of lncRNAs in regulating T cell differentiation, function and exhaustion during homeostasis and cancer. We discuss the different molecular mechanisms of lncRNAs and highlight lncRNAs that can serve as novel targets to modulate T cell function or to improve the response to cancer immunotherapies by modulating the immunosuppressive tumor microenvironment.
【 授权许可】
Unknown
Copyright © 2023 Erber and Herndler-Brandstetter
【 预 览 】
Files | Size | Format | View |
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RO202310109376988ZK.pdf | 1522KB | download |