The thalamic reuniens is associated with consolidation of non-spatial memory too

Frontiers in Behavioral Neuroscience

Behavioral Neuroscience

Jennifer J. Hamilton¹  John C. Dalrymple-Alford² 

[1] School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand;Brain Research New Zealand – Rangahau Roro Aotearoa, a National Centre of Research Excellence, University of Auckland, Auckland, New Zealand;Brain Research New Zealand – Rangahau Roro Aotearoa, a National Centre of Research Excellence, University of Otago, Dunedin, New Zealand;School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand;Brain Research New Zealand – Rangahau Roro Aotearoa, a National Centre of Research Excellence, University of Auckland, Auckland, New Zealand;Brain Research New Zealand – Rangahau Roro Aotearoa, a National Centre of Research Excellence, University of Otago, Dunedin, New Zealand;New Zealand Brain Research Institute, Christchurch, New Zealand;

关键词: nucleus reuniens;    memory;    consolidation;    recall;    paired-associate;    non-spatial;   

DOI  :  10.3389/fnbeh.2023.1215625

 received in 2023-05-02, accepted in 2023-07-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

The nucleus reuniens (RE) is situated in the midline thalamus and provides a key link between the hippocampus and prefrontal cortex. This anatomical relationship positions the Re as an ideal candidate to facilitate memory consolidation. However, there is no evidence that this role extends beyond spatial memory and contextual fear memory, which are both strongly associated with hippocampal function. We, therefore, trained intact male Long–Evans rats on an odor–trace–object paired-associate task where the explicit 10-s delay between paired items renders the task sensitive to hippocampal function. Neurons in the RE showed significantly increased activation of the immediate early gene (Zif268) when rats were re-tested for previous non-spatial memory 25 days after acquisition training, compared to a group tested at 5-days post-acquisition, as well as a control group tested 25 days after acquisition but with a new pair of non-spatial stimuli, and home cage controls. The remote recall group also showed relatively augmented IEG expression in the superficial layers of the medial PFC (anterior cingulate cortex and prelimbic cortex). These findings support the conclusion that the RE is preferentially engaged during remote recall in this non-spatial task and thus has a role beyond spatial memory and contextual fear memory.

【 授权许可】

Unknown   
Copyright © 2023 Hamilton and Dalrymple-Alford.