Using the photoplethysmography method to monitor age-related changes in the cardiovascular system

Frontiers in Physiology

Physiology

Danijela Lepojević-Stefanović¹  Katarina Žikić²  Nebojša Milošević³  Zorica Nestorović³  Dejan Žikić³  Biljana Djurić⁴ 

[1] Division of Cardiology, Department of Internal Medicine, Belgrade, Serbia;Faculty of Physics, University of Belgrade, Belgrade, Serbia;Institute of Biophysics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia;Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia;

关键词: photoplethysmography;    sensor;    cardiovascular age;    blood flow waveform;    detrended fluctuation analysis;   

DOI  :  10.3389/fphys.2023.1191272

 received in 2023-03-21, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Aging is a physiological process characterized by progressive changes in all organ systems. In the last few decades, the elderly population has been growing, so the scientific community is focusing on the investigation of the aging process, all in order to improve the quality of life in elderly. One of the biggest challenges in studying the impact of the aging on the human body represents the monitoring of the changes that inevitably occur in arterial blood vessels. Therefore, the medical community has invested a great deal of effort in studying and discovering new methods and tools that could be used to monitor the changes in arterial blood vessels caused by the aging process. The goal of our research was to develop a new diagnostic method using a photoplethysmographic sensor and to examine the impact of the aging process on the cardiovascular system in adults. Long-term recorded arterial blood flow waveforms were analyzed using detrended fluctuation analysis.Materials and Methods: The study included 117 respondents, aged 20–70 years. The waveform of the arterial blood flow was recorded for 5 min, with an optical sensor placed above the left common carotid artery, simultaneously with a single-channel ECG. For each cardiac cycle, the blood flow amplitude was determined, and a new time series was formed, which was analyzed non-linearly (DFA method). The values of the scalar coefficients α1 and α2, particularly their ratio (α1/α2) were obtained, which were then monitored in relation to the age of the subjects.Result: The values of the scalar ratio (α1/α2) were significantly different between the subjects older and younger than 50 years. The value of the α1/α2 decreased exponentially with the aging. In the population of middle-aged adults, this ratio had a value around 1, in young adults the value was exclusively higher than 1 and in older adults the value was exclusively lower than 1.Conclusion: The results of this study indicated that the aging led to a decrease in the α1/α2 in the population of healthy subjects. With this non-invasive method, changes in the cardiovascular system due to aging can be detected and monitored.

【 授权许可】

Unknown   
Copyright © 2023 Djurić, Žikić, Nestorović, Lepojević-Stefanović, Milošević and Žikić.