Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health

Frontiers in Physiology

Physiology

Zhuo Zhang¹  Xiaohu Xu²  Xiao Wu²  Haoxu Dong²  Wenwen Ma²  Kunkun Song²  Yanjing Huang³  Fan Li³  Runan Hu³  Zhuo Liu³  Yuli Geng³  Yufan Song⁴ 

[1] Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: microplastics;    nanoplastics;    reproductive toxicity;    cross-generational;    environmental toxicants;   

DOI  :  10.3389/fphys.2023.1254886

 received in 2023-07-10, accepted in 2023-08-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Microplastics (MPs) and nanoplastics (NPs) are emergent pollutants, which have sparked widespread concern. They can infiltrate the body via ingestion, inhalation, and cutaneous contact. As such, there is a general worry that MPs/NPs may have an impact on human health in addition to the environmental issues they engender. The threat of MPs/NPs to the liver, gastrointestinal system, and inflammatory levels have been thoroughly documented in the previous research. With the detection of MPs/NPs in fetal compartment and the prevalence of infertility, an increasing number of studies have put an emphasis on their reproductive toxicity in female. Moreover, MPs/NPs have the potential to interact with other contaminants, thus enhancing or diminishing the combined toxicity. This review summarizes the deleterious effects of MPs/NPs and co-exposure with other pollutants on female throughout the reproduction period of various species, spanning from reproductive failure to cross-generational developmental disorders in progenies. Although these impacts may not be directly extrapolated to humans, they do provide a framework for evaluating the potential mechanisms underlying the reproductive toxicity of MPs/NPs.

【 授权许可】

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Copyright © 2023 Geng, Liu, Hu, Huang, Li, Ma, Wu, Dong, Song, Xu, Zhang and Song.