Awakening the dormant: Role of axonal guidance cues in stress-induced reorganization of the adult prefrontal cortex leading to depression-like behavior

Frontiers in Neural Circuits

Neural Circuits

Zhipeng Niu¹  Radu Gabriel Avramescu¹  Cecilia Flores²  Ashraf Mahmud³ 

[1] Douglas Mental Health University Institute, Montréal, QC, Canada;Douglas Mental Health University Institute, Montréal, QC, Canada;Department of Psychiatry, Neurology, and Neurosurgery, McGill University, Montréal, QC, Canada;Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada;Douglas Mental Health University Institute, Montréal, QC, Canada;

关键词: Netrin-1;    social defeat;    post-mortem;    MDD;    ephrin;    slit;    DCC;    semaphorin;   

DOI  :  10.3389/fncir.2023.1113023

 received in 2022-11-30, accepted in 2023-03-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Major depressive disorder (MDD) is a chronic and disabling disorder affecting roughly 280 million people worldwide. While multiple brain areas have been implicated, dysfunction of prefrontal cortex (PFC) circuitry has been consistently documented in MDD, as well as in animal models for stress-induced depression-like behavioral states. During brain development, axonal guidance cues organize neuronal wiring by directing axonal pathfinding and arborization, dendritic growth, and synapse formation. Guidance cue systems continue to be expressed in the adult brain and are emerging as important mediators of synaptic plasticity and fine-tuning of mature neural networks. Dysregulation or interference of guidance cues has been linked to depression-like behavioral abnormalities in rodents and MDD in humans. In this review, we focus on the emerging role of guidance cues in stress-induced changes in adult prefrontal cortex circuitry and in precipitating depression-like behaviors. We discuss how modulating axonal guidance cue systems could be a novel approach for precision medicine and the treatment of depression.

【 授权许可】

Unknown   
Copyright © 2023 Mahmud, Avramescu, Niu and Flores.