Cortical thinning in male obstructive sleep apnoea patients with excessive daytime sleepiness

Frontiers in Neurology

Neurology

Lirong Ji¹  Erlei Wang¹  Chaohong Cheng²  Rui Chen²  Jing Wang²  Tong Su²  Fei Han³  Shuqing Wu³  Daniel J. Cox⁴  Yezhou Li⁵ 

[1] Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China;Department of Respiratory and Critical Care, The Second Affiliated Hospital of Soochow University, Suzhou, China;Department of Sleep Centre, The Second Affiliated Hospital of Soochow University, Suzhou, China;Department of Sleep Centre, The Second Affiliated Hospital of Soochow University, Suzhou, China;Division of Psychology, Communication, and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;School of Biological Sciences, University of Manchester, Manchester, United Kingdom;

关键词: excessive daytime sleepiness;    Epworth sleepiness scale;    obstructive sleep apnoea;    magnetic resonance imaging;    cortical thickness;   

DOI  :  10.3389/fneur.2023.1019457

 received in 2022-08-15, accepted in 2023-02-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and purposeObstructive sleep apnoea is associated with excessive daytime sleepiness due to sleep fragmentation and hypoxemia, both of which can lead to abnormal brain morphology. However, the pattern of brain structural changes associated with excessive daytime sleepiness is still unclear. This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea.Materials and methods61 male patients with newly diagnosed obstructive sleep apnoea were included in the present study. Polysomnography and structural MRI were performed for each participant. Subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale score. Surface-based morphometric analysis was performed using Statistical Parametric Mapping 12 and Computational Anatomy 12 toolboxes to extract cortical thickness.ResultsUsing the median Epworth Sleepiness Scale score, patients were divided into the non-sleepiness group and the sleepiness group. The cortical thickness was markedly thinner in the sleepiness group in the left temporal, frontal, and parietal lobe and bilateral pre- and postcentral gyri (pFWE < 0.05). There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score. After adjusting for age, body mass index, and obstructive sleep apnoea severity, the Epworth Sleepiness Scale score remained an independent factor affecting the cortical thickness of the left middle temporal lobe, transverse temporal and temporal pole.ConclusionSubjective daytime sleepiness is associated with decreased cortical thickness, and the Epworth Sleepiness Scale score may be of utility as a clinical marker of brain injury in patients with obstructive sleep apnoea.

【 授权许可】

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Copyright © 2023 Li, Wang, Ji, Cheng, Su, Wu, Han, Cox, Wang and Chen.