Association of GSDMD with microvascular-ischemia reperfusion injury after ST-elevation myocardial infarction

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Shihua Cui¹  Shenghui Zhao²  Min Lu²  Yingjie Chu²  Shujuan Dong²  Wenjing Sun³  Fan Yang⁴  Chunqiu Wang⁵  Yan Wang⁵ 

[1] Department of Cardiology, Dalian Medical University, Dalian, China;Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China;Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China;Microbiome Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China;Department of Cardiology, Second Affiliated Hospital of Kunming Medical University, Kunming, China;Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China;

关键词: ST-segment elevation myocardial infarction;    magnetic resonance imaging;    microvascular dysfunction;    GSDMD;    IMH;    MVO;   

DOI  :  10.3389/fcvm.2023.1138352

 received in 2023-02-28, accepted in 2023-05-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesLittle is known about the clinical prognosis of gasdermin D (GSDMD) in patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the association of GSDMD with microvascular injury, infarction size (IS), left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACEs), in STEMI patients with primary percutaneous coronary intervention (pPCI).MethodsWe retrospectively analyzed 120 prospectively enrolled STEMI patients (median age 53 years, 80% men) treated with pPCI between 2020 and 2021 who underwent serum GSDMD assessment and cardiac magnetic resonance (CMR) within 48 h post-reperfusion; CMR was also performed at one year follow-up.ResultsMicrovascular obstruction was observed in 37 patients (31%). GSDMD concentrations ≧ median (13 ng/L) in patients were associated with a higher risk of microvascular obstruction and IMH (46% vs. 19%, P = 0.003; 31% vs. 13%, P = 0.02, respectively), as well as with a lower LVEF both in the acute phase after infarction (35% vs. 54%, P < 0.001) and in the chronic phase (42% vs. 56%, P < 0.001), larger IS in the acute (32% vs. 15%, P < 0.001) and in the chronic phases (26% vs. 11%, P < 0.001), and larger left ventricular volumes (119 ± 20 vs. 98 ± 14, P = 0.003) by CMR. Univariable and multivariable Cox regression analysis results showed that patients with GSDMD concentrations ≧ median (13 ng/L) had a higher incidence of MACE (P < 0.05).ConclusionsHigh GSDMD concentrations in STEMI patients are associated with microvascular injury (including MVO and IMH), which is a powerful MACE predictor. Nevertheless, the therapeutic implications of this relation need further research.

【 授权许可】

Unknown   
© 2023 Sun, Wang, Cui, Wang, Zhao, Lu, Yang, Dong and Chu.