Inflammation mediates the effect of adiposity and lipid metabolism indicators on the embryogenesis of PCOS women undergoing in vitro fertilization/intracytoplasmic sperm injection

Frontiers in Endocrinology

Endocrinology

Tian Tian¹  Ning Huang¹  Rui Yang¹  Hongbin Chi¹  Lixue Chen¹  Huahua Jiang¹  Xiaoyu Long¹  Jie Qiao²  Huifeng Shi³ 

[1] Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing, China;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China;Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing, China;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China;Beijing Advanced Innovation Center for Genomics, Peking University, Beijing, China;Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China;National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;National Centre for Healthcare Quality Management in Obstetrics, Beijing, China;

关键词: PCOS;    adiposity;    lipid metabolism;    inflammation;    mediating effect;    IVF/ICSI outcomes;   

DOI  :  10.3389/fendo.2023.1198602

 received in 2023-04-01, accepted in 2023-06-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPolycystic ovary syndrome (PCOS) is a complex reproductive endocrine and metabolic disease affecting women of reproductive age. The low-grade chronic inflammation in PCOS is considered to be associated with obesity and dyslipidemia. We aim to investigate the potential mediating role of white blood cell (WBC) count, a representative inflammatory marker, in the effect of adiposity and lipid metabolism indicators on IVF/ICSI outcomes in PCOS women.MethodsWe conducted a retrospective cohort study of 1,534 PCOS women who underwent their first IVF/ICSI cycles with autologous oocytes at a reproductive center from January 2018 to December 2020. The associations between PCOS women’s adiposity and lipid metabolism indicators and WBC count and IVF/ICSI outcomes were examined using multivariable generalized linear models. Mediation analyses were conducted to evaluate the possible mediating role of WBC count.ResultsWe found significant dose-dependent correlations between adiposity and lipid metabolism indicators and IVF/ICSI outcomes (i.e., hormone levels on the ovulatory triggering day, oocyte development outcomes, fertilization, early embryo development outcomes, and pregnancy outcomes) (all p < 0.05), as well as between adiposity and lipid metabolism indicators and WBC count (all p < 0.001). Increasing WBC count was associated with adverse oocyte and embryonic development outcomes (all p < 0.05). Mediation analyses suggested that increasing serum TG and LDL-C levels and decreasing serum HDL-C level were significantly associated with reduced high-quality Day 3 embryo count in PCOS women, with 21.51%, 9.75%, and 14.10% mediated by WBC count, respectively (all p < 0.05).ConclusionsWe observed significant associations between lipid metabolism indicators and high-quality Day 3 embryo count in PCOS women, partially mediated by inflammation-related mechanisms, suggesting the potential intervention target for improving embryo quality in PCOS women.

【 授权许可】

Unknown   
Copyright © 2023 Jiang, Chen, Tian, Shi, Huang, Chi, Yang, Long and Qiao