Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases

Frontiers in Immunology

Immunology

Mohsen Rokni¹  Mina Sadeghi Shaker²  Mahdi Mahmoudi³  Elham Farhadi³ 

[1] Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Department of Immunology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran;Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran;Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran;Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran;

关键词: autoimmune inflammatory diseases;    Ras signaling;    rheumatoid arthritis;    systemic lupus erythematosus;    systemic sclerosis;    ankylosing spondylitis;   

DOI  :  10.3389/fimmu.2023.1151246

 received in 2023-01-25, accepted in 2023-04-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

The Ras (rat sarcoma virus) is a GTP-binding protein that is considered one of the important members of the Ras-GTPase superfamily. The Ras involves several pathways in the cell that include proliferation, migration, survival, differentiation, and fibrosis. Abnormalities in the expression level and activation of the Ras family signaling pathway and its downstream kinases such as Raf/MEK/ERK1-2 contribute to the pathogenic mechanisms of rheumatic diseases including immune system dysregulation, inflammation, and fibrosis in systemic sclerosis (SSc); destruction and inflammation of synovial tissue in rheumatoid arthritis (RA); and autoantibody production and immune complexes formation in systemic lupus erythematosus (SLE); and enhance osteoblast differentiation and ossification during skeletal formation in ankylosing spondylitis (AS). In this review, the basic biology, signaling of Ras, and abnormalities in this pathway in rheumatic diseases including SSc, RA, AS, and SLE will be discussed.

【 授权许可】

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Copyright © 2023 Sadeghi Shaker, Rokni, Mahmoudi and Farhadi