An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Wenhe Zhang¹  Shuqi Hang¹  Baike Ning¹  Caiwen Mao¹  Dan Li² 

[1] Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China;Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China;Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States;

关键词: bridging factors;    autophagy;    Nrf2-Keap1;    TRIM16;    SQSTM1;    Sestrin2;   

DOI  :  10.3389/fcell.2023.1232241

 received in 2023-05-31, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Macroautophagy/autophagy is a lysosome-dependent catabolic pathway for the degradation of intracellular proteins and organelles. Autophagy dysfunction is related to many diseases, including lysosomal storage diseases, cancer, neurodegenerative diseases, cardiomyopathy, and chronic metabolic diseases, in which increased reactive oxygen species (ROS) levels are also observed. ROS can randomly oxidize proteins, lipids, and DNA, causing oxidative stress and damage. Cells have developed various antioxidant pathways to reduce excessive ROS and maintain redox homeostasis. Treatment targeting only one aspect of diseases with autophagy dysfunction and oxidative stress shows very limited effects. Herein, identifying the bridging factors that can regulate both autophagy and antioxidant pathways is beneficial for dual-target therapies. This review intends to provide insights into the current identified bridging factors that connect autophagy and Nrf2 antioxidant pathway, as well as their tight interconnection with each other. These factors could be potential dual-purpose targets for the treatment of diseases implicated in both autophagy dysfunction and oxidative stress.

【 授权许可】

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Copyright © 2023 Ning, Hang, Zhang, Mao and Li.