Visceral fat correlates with insulin secretion and sensitivity independent of BMI and subcutaneous fat in Chinese with type 2 diabetes

Frontiers in Endocrinology

Endocrinology

Xiaobin Zheng¹  Lingling Xu¹  Xiaoming Wen¹  Haishan Huang¹  Jingyi Zhong¹  Yanting Zhou¹ 

[1] Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China;The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China;

关键词: insulin sensitivity;    insulin secretion;    abdominal obesity;    visceral fat;    type 2 diabetes mellitus;   

DOI  :  10.3389/fendo.2023.1144834

 received in 2023-01-15, accepted in 2023-02-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimClinical heterogeneity exists in overall obesity and abdominal obesity in terms of insulin secretion and sensitivity. Further, the impact of visceral fat (VF) on the first- and second-phase insulin secretion (FPIS and SPIS) is controversial. We aim to investigate insulin secretion and sensitivity in Chinese patients with T2DM according to different BMI and VF levels.MethodsThis study enrolled 300 participants. A dual bioelectrical impedance analyzer was used to assess the visceral and subcutaneous fat area (VFA and SFA). VF levels were categorized as normal or high, with the cutoff value of 100 cm2. FPIS and SPIS were evaluated by arginine stimulation test and standardized steamed bread meal tolerance test, respectively. β-cell function (HOMA2-β), insulin resistance (HOMA2-IR), and Gutt’s insulin sensitivity index (Gutt-ISI) were also calculated. Spearman’s correlation analysis and multivariate linear regression analysis were adopted for statistical analysis.ResultsParticipants were categorized into four groups: normal weight-normal VF, normal weight-high VF, overweight/obese-normal VF and overweight/obese-high VF. Multivariate linear regression showed that both VFA and SFA were correlated with FPIS, HOMA2-IR and Gutt-ISI after controlling for gender and diabetes duration. After further adjustment for BMI and VFA, some associations of SFA with insulin secretion and sensitivity disappeared. After adjustment for gender, diabetes duration, BMI and SFA, VFA was positively correlated with FPIS, SPIS and HOMA2-IR. Subjects with overweight/obese-high VF were more likely to have higher FPIS, HOMA2-IR and lower Gutt-ISI (all p < 0.05).ConclusionVF affects both FPIS and SPIS, and worsens insulin sensitivity independent of BMI and subcutaneous fat in Chinese patients with T2DM.Clinical trial registrationhttp://www.chictr.org.cn, identifier ChiCTR2200062884.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Zheng, Wen, Zhong, Zhou and Xu