Omega-3 index as risk factor in psychiatric diseases: a narrative review

Frontiers in Psychiatry

Psychiatry

Helena Sofia Antao¹  Maria Luisa Figueira¹  Ema Sacadura-Leite²  Narcisa Maria Bandarra³ 

[1] Faculty of Medicine, University of Lisbon, Lisbon, Portugal;Faculty of Medicine, University of Lisbon, Lisbon, Portugal;CISP – Centro de Investigação em Saúde Pública, ENSP, Lisbon, Portugal;Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisbon, Portugal;Portuguese Institute for Sea and Atmosphere (IPMA), Lisbon, Portugal;

关键词: Omega-3 index;    biomarker;    risk factor;    depression;    bipolar disorder;    psychosis;    schizophrenia;    dementia;   

DOI  :  10.3389/fpsyt.2023.1200403

 received in 2023-04-04, accepted in 2023-07-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Numerous studies have described associations between the omega-3 index (defined as the RBC percentage of EPA and DHA) and mental conditions, but no risk stratification or target value has gathered consensus so far. This narrative review aims to summarize the published data on the association between omega-3 index and mental illness and to contribute to the concept of an omega-3 index in the field of mental health. The bibliographic searches have been carried out in PubMed, Scopus and Web of Science databases to find relevant English language original research studies related to that association. The study search and selection process were registered in a PRISMA flow. Thirty-six studies were included in this review examining the links between omega-3 index and postpartum depression (3), major depression (15), major depression and bipolar disorder (1), bipolar disorder (4), schizophrenia and major depression (1), schizophrenia and other psychosis (5) and dementia (7). Thirty of these studies found either significant differences in omega-3 index between patients and controls or inverse relationships between omega-3 index and disease severity. The published evidence is compelling enough to suggest omega-3 index as a risk factor for some psychiatric diseases, specifically, major depression, postpartum depression, psychosis, and dementia. In occidental populations, we propose a risk threshold of (a) 4–5% in major depression and dementia, (b) 5% in postpartum depression, and (c) 4% for psychosis transition.

【 授权许可】

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Copyright © 2023 Antao, Sacadura-Leite, Bandarra and Figueira.