The function of histone methylation and acetylation regulators in GBM pathophysiology

Frontiers in Oncology

Oncology

Angela Hardi¹  Timothy Woodiwiss²  Hiroko Yano³  Albert H. Kim³  Colin McCornack⁴ 

[1] Bernard Becker Medical Library, Washington University School of Medicine, St. Louis, MO, United States;Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States;Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa, IA, United States;Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States;The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States;Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, United States;

关键词: glioblastoma;    histone postranslational modifications;    histone post translational modifications;    histone acetylation;    histone methylation;    glioblastoma epigenomics;   

DOI  :  10.3389/fonc.2023.1144184

 received in 2023-01-13, accepted in 2023-03-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly immunosuppressive tumor microenvironment, and nearly universal recurrence. The application of various genomic approaches has allowed us to understand the core molecular signatures, transcriptional states, and DNA methylation patterns that define GBM. Histone posttranslational modifications (PTMs) have been shown to influence oncogenesis in a variety of malignancies, including other forms of glioma, yet comparatively less effort has been placed on understanding the transcriptional impact and regulation of histone PTMs in the context of GBM. In this review we discuss work that investigates the role of histone acetylating and methylating enzymes in GBM pathogenesis, as well as the effects of targeted inhibition of these enzymes. We then synthesize broader genomic and epigenomic approaches to understand the influence of histone PTMs on chromatin architecture and transcription within GBM and finally, explore the limitations of current research in this field before proposing future directions for this area of research.

【 授权许可】

Unknown   
Copyright © 2023 McCornack, Woodiwiss, Hardi, Yano and Kim