The fibroblast growth factor system in cognitive disorders and dementia

Frontiers in Neuroscience

Neuroscience

Wujianwen Zhai¹  Yujing Jin¹  Tong Zhang¹  Shijing Huang²  Manman Xu²  Juhua Pan² 

[1] Traditional Chinese Medicine Research and Development Center, Guang' Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;null;

关键词: fibroblast growth factor;    fibroblast growth factor receptor;    dementia;    cognitive disorders;    Alzheimer’s disease;    neurodegenerative diseases;   

DOI  :  10.3389/fnins.2023.1136266

 received in 2023-01-02, accepted in 2023-04-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cognitive impairment is the core precursor to dementia and other cognitive disorders. Current hypotheses suggest that they share a common pathological basis, such as inflammation, restricted neurogenesis, neuroendocrine disorders, and the destruction of neurovascular units. Fibroblast growth factors (FGFs) are cell growth factors that play essential roles in various pathophysiological processes via paracrine or autocrine pathways. This system consists of FGFs and their receptors (FGFRs), which may hold tremendous potential to become a new biological marker in the diagnosis of dementia and other cognitive disorders, and serve as a potential target for drug development against dementia and cognitive function impairment. Here, we review the available evidence detailing the relevant pathways mediated by multiple FGFs and FGFRs, and recent studies examining their role in the pathogenesis and treatment of cognitive disorders and dementia.

【 授权许可】

Unknown   
Copyright © 2023 Zhai, Zhang, Jin, Huang, Xu and Pan.