The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis

Frontiers in Immunology

Immunology

Lei Shen¹  Lanlan Zha¹  Yuan Xia¹  Jing Wu¹  Hesheng Luo¹  Shuai Peng¹  Xiaoyun Yu²  Ke Xu³  Li Zhang³ 

[1] Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China;Hubei Key Laboratory of Digestive Diseases, Wuhan, China;Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China;

关键词: Nrf2;    ulcerative colitis;    oxidative stress;    intestinal fibrosis;    colorectal cancer;   

DOI  :  10.3389/fimmu.2023.1200111

 received in 2023-04-04, accepted in 2023-05-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the colorectal mucosa and submucosa, the incidence of which has been on the rise in recent years. Nuclear factor erythroid 2-related factor 2 (Nrf2), known for its key function as a transcription factor, is pivotal in inducing antioxidant stress and regulating inflammatory responses. Numerous investigations have demonstrated the involvement of the Nrf2 pathway in maintaining the development and normal function of the intestine, the development of UC, and UC-related intestinal fibrosis and carcinogenesis; meanwhile, therapeutic agents targeting the Nrf2 pathway have been widely investigated. This paper reviews the research progress of the Nrf2 signaling pathway in UC.

【 授权许可】

Unknown   
Copyright © 2023 Peng, Shen, Yu, Zhang, Xu, Xia, Zha, Wu and Luo