期刊论文详细信息
Frontiers in Bioengineering and Biotechnology | |
Evaluation of polyetheretherketone composites modified by calcium silicate and carbon nanotubes for bone regeneration: mechanical properties, biomineralization and induction of osteoblasts | |
Bioengineering and Biotechnology | |
Kun Shi1  Chengdong Xiong2  Yao Wang3  Shuhao Yang3  Xulin Hu4  Jian He5  Yijun Liao6  Jianfei Cao6  | |
[1]Cancer Center and State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China | |
[2]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China | |
[3]Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China | |
[4]Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China | |
[5]Cancer Center and State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China | |
[6]College of Basic Medical and Forensic Medicine, Henan University of Science and Technology, Luoyang, China | |
[7]School of Materials and Environmental Engineering, Chengdu Technological University, Chengdu, China | |
关键词: polyetheretherketone; carbon nanotubes; calcium silicate; musculoskeletal regeneration; mechanical strength; biocompatibility; biological mineralization; | |
DOI : 10.3389/fbioe.2023.1271140 | |
received in 2023-08-01, accepted in 2023-08-15, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Desired orthopedic implant materials must have a good biological activity and possess appropriate mechanical property that correspond to those of human bone. Although polyetheretherketone (PEEK) has displayed a promising application prospect in musculoskeletal and dentistry reconstruction thanks to its non-biodegradability and good biocompatibility in the body, the poor osseointegration and insufficient mechanical strength have significantly limited its application in the repair of load-bearing bones and surgical operations. In this study, carbon nanotubes (CNT)/calcium silicate (CS)/polyetheretherketone ternary composites were fabricated for the first time. The addition of CS was mainly aimed at improving biological activities and surface hydrophilicity, but it inevitably compromised the mechanical strength of PEEK. CNT can reinforce the composites even when brittle CS was introduced and further upgraded the biocompatibility of PEEK. The CNT/CS/PEEK composites exhibited higher mechanical strengths in tensile and bending tests, 64% and 90% higher than those of brittle CS/PEEK binary composites. Besides, after incorporation of CNT and CS into PEEK, the hydrophilicity, surface roughness and ability to induce apatite-layer deposition were significantly enhanced. More importantly, the adhesion, proliferation, and osteogenic differentiation of mouse embryo osteoblasts were effectively promoted on CNT/CS/PEEK composites. In contrast to PEEK, these composites exhibited a more satisfactory biocompatibility and osteoinductive activity. Overall, these results demonstrate that ternary CNT/CS/PEEK composites have the potential to serve as a feasible substitute to conventional metal alloys in musculoskeletal regeneration and orthopedic implantation.【 授权许可】
Unknown
Copyright © 2023 Cao, Yang, Liao, Wang, He, Xiong, Shi and Hu.
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