One-year outcomes in cardiogenic shock triggered by supraventricular tachycardia: an analysis of the FRENSHOCK multicenter prospective registry

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Sebastien Champion¹  Laurent Bonello²  Brahim Harbaoui³  François Roubille⁴  Etienne Puymirat⁵  Nicolas Combaret⁶  Guillaume Leurent⁷  Gerald Vanzetto⁸  Benoit Lattuca⁹  Edouard Gerbaud^1,10  Hadi Khachab^1,11  Eric Bonnefoy^1,12  Philippe Maury^1,13  Miloud Cherbi^1,13  Caroline Biendel-Picquet^1,13  Meyer Elbaz^1,13  Clément Delmas^1,14  Vincent Labbe^1,15  Francis Schneider^1,16  Bruno Levy^1,17  Marie-France Seronde^1,18  Jeremy Bourenne^1,19  Pascal Lim^2,20  Benjamin Marchandot^2,21  Guillaume Schurtz^2,22  Nicolas Lamblin^2,22 

[1]Anesthesiology and Intensive Care Department, Clinique de Parly 2, Ramsay Générale de Santé, Le Chesnay, France

[2]Cardiology Department, Hopital Nord, AP-HM, Aix-Marseille Université, Marseille, France

[3]Intensive Care Unit, Department of Cardiology, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille, France

[4]Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), Marseille, France

[5]Cardiology Department, Hôpital Croix-Rousse and Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France

[6]University of Lyon, CREATIS, UMR5220, INSERM U1044, INSA-15, Lyon, France

[7]Cardiology Department, PhyMedExp, Université de Montpellier, INSERM, CNRS, INI-CRT, CHU de Montpellier, Montpellier, France

[8]Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Paris, France

[9]Université de Paris, Paris, France

[10]Department of Cardiology, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France

[11]Department of Cardiology, CHU Rennes, Inserm, LTSI—UMR 1099, Univ Rennes 1, Rennes, France

[12]Department of Cardiology, Hôpital de Grenoble, La Tronche, France

[13]Department of Cardiology, Nîmes University Hospital, Montpellier University, Nîmes, France

[14]Intensive Cardiac Care Unit and Interventional Cardiology, Hôpital Cardiologique du Haut Lévêque, Pessac, France

[15]Bordeaux Cardio-Thoracic Research Centre, U1045, Bordeaux University, Hôpital Xavier Arnozan, Pessac, France

[16]Intensive Cardiac Care Unit, Cardiology Department, CH d'Aix-en-Provence, Aix-en-Provence, France

[17]Intensive Cardiac Care Unit, Lyon Brom University Hospital, Lyon, France

[18]Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France

[19]Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France

[20]Intensive Cardiac Care Unit, Rangueil University Hospital, Toulouse, France

[21]Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR-1048, National Institute of Health and Medical Research (INSERM), Toulouse, France

[22]REICATRA, Institut Saint Jacques, CHU de Toulouse, Toulouse, France

[23]Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Tenon,, Paris, France

[24]Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

[25]Réanimation Médicale Brabois, CHRU Nancy, Vandoeuvre-les Nancy, France

[26]Service de Cardiologie CHU, Besançon, France

[27]Service de Réanimation des Urgences, AP-HM, Hôpital de La Timone, Marseille, France

[28]Univ Paris Est Créteil, INSERM, IMRB, Créteil, France

[29]Cardiology Department, AP-HP, Hôpital Universitaire Henri-Mondor, Service de Cardiologie, Créteil, France

[30]Université de Strasbourg, Pôle D'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Strasbourg, France

[31]Urgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167, Lille, France

关键词: cardiogenic shock;    supraventricular tachycardia;    epidemiology;    prognosis;    mortality;   

DOI  :  10.3389/fcvm.2023.1167738

 received in 2023-02-16, accepted in 2023-08-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCardiogenic shock (CS) is the most severe form of heart failure (HF), resulting in high early and long-term mortality. Characteristics of CS secondary to supraventricular tachycardia (SVT) are poorly reported. Based on a large registry of unselected CS, we aimed to compare 1-year outcomes between SVT-triggered and non-SVT-triggered CS.MethodsFRENSHOCK is a French prospective registry including 772 CS patients from 49 centers. For each patient, the investigator could report 1–3 CS triggers from a pre-established list (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance, and others). In this study, 1-year outcomes [rehospitalizations, mortality, heart transplantation (HTx), ventricular assist devices (VAD)] were analyzed and adjusted for independent predictive factors.ResultsAmong 769 CS patients included, 100 were SVT-triggered (13%), of which 65 had SVT as an exclusive trigger (8.5%). SVT-triggered CS patients exhibited a higher proportion of male individuals with a more frequent history of cardiomyopathy or chronic kidney disease and more profound CS (biventricular failure and multiorgan failure). At 1 year, there was no difference in all-cause mortality (43% vs. 45.3%, adjusted HR 0.9 (95% CI 0.59–1.39), p = 0.64), need for HTx or VAD [10% vs. 10%, aOR 0.88 (0.41–1.88), p = 0.74], or rehospitalizations [49.4% vs. 44.4%, aOR 1.24 (0.78–1.98), p = 0.36]. Patients with SVT as an exclusive trigger presented more 1-year rehospitalizations [52.8% vs. 43.3%, aOR 3.74 (1.05–10.5), p = 0.01].ConclusionSVT is a frequent trigger of CS alone or in association in more than 10% of miscellaneous CS cases. Although SVT-triggered CS patients were more comorbid with more pre-existing cardiomyopathies and HF incidences, they presented similar rates of mortality, HTx, and VAD at 1 year, arguing for a better overall prognosis.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier: NCT02703038.

【 授权许可】

Unknown   
© 2023 Cherbi, Bonnefoy, Lamblin, Gerbaud, Bonello, Roubille, Levy, Champion, Lim, Schneider, Elbaz, Khachab, Bourenne, Seronde, Schurtz, Harbaoui, Vanzetto, Combaret, Labbe, Marchandot, Lattuca, Biendel-Picquet, Leurent, Puymirat, Maury and Delmas.